◀ Back to WNK1

MYLK — WNK1

Text-mined interactions from Literome

Wadgaonkar et al., J Cell Biochem 2005 : Furthermore, our data revealed that inhibition of MLCK attenuated the TNFalpha induced IkappaB phosphorylation, translocation of p65 , NFkappaB-DNA binding, and NFkappaB transcriptional activity
Ye et al., Am J Physiol Gastrointest Liver Physiol 2006 : Additionally, siRNA silencing of NF-kappaB p65 also prevented the TNF-alpha increase in MLCK promoter activity ... NF-kappaB p50/p65 activation of the MLCK promoter then leads to a stepwise increase in MLCK transcription, expression and activity, and MLCK mediated opening of the intestinal TJ barrier
Al-Sadi et al., J Interferon Cytokine Res 2012 (Crohn Disease...) : The intestinal tissue-specific silencing of NF-?B p65 inhibited the IL-1ß induced increase in intestinal permeability and increase in MLCK expression ... These data suggested that the mechanism of IL-1ß induced increase in mouse intestinal permeability in vivo involved NF-?B p65 induced activation of the mouse enterocyte MLCK gene