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CASP9 — WAS

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Campbell et al., Neuropharmacology 2001 (Nerve Degeneration) : THC also promoted translocation of mitochondrial cytochrome c to the cytosol and increased the activity of the cysteine protease caspase-3 , in a PTX-sensitive manner
Sarafian et al., Toxicol Appl Pharmacol 2001 (Necrosis) : Delta ( 9 ) -THC also inhibited Fas induced caspase-3 activity in A549 cells
Lombard et al., Leuk Res 2005 (Leukemia, T-Cell) : Caspase-2 inhibitor blocked THC induced caspase-3 in wild-type Jurkat cells but not loss of Deltapsi ( m )
Chang et al., Fish Shellfish Immunol 2009 : For shrimp transferred from 28 +/- 1.0 to 22 +/- 0.5 degrees C after 2 and 7 days, the THC decreased by 17.9 % and 18.0 %, but the NE concentration, caspase-3 transcription and activity levels, and apoptotic cell rate increased by 62.5 % and 37.3 %, 5100.0 % and 446.6 %, 148.6 % and 152.0 %, and 88.7 % and 200.1 %, respectively, compared to those of shrimp held at 28 +/- 0.5 degrees C which served as the control
Zhu et al., J Pharmacol Exp Ther 1998 : These data suggest that THC treatment of cultured immune cells induces apoptosis through the regulation of Bcl-2 and caspase activity