◀ Back to USP7

DAXX — USP7

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: HAUSP/DAXX complex (USP7-DAXX) → RASSF1A (RASSF1) (modification, activates) Tang et al., Nat Cell Biol 2006, Song et al., EMBO J 2008
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: USP7 — DAXX (physical association, affinity chromatography technology) Giovinazzi et al., Cell Death Differ 2013*
• IRef Biogrid Interaction: USP7 — DAXX (physical association, affinity chromatography technology) Kumar et al., Oncogenesis 2013*
• IRef Biogrid Interaction: USP7 — DAXX (direct interaction, pull down) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: USP7 — DAXX (physical association, affinity chromatography technology) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: USP7 — DAXX (colocalization, imaging technique) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: USP7 — DAXX (physical association, affinity chromatography technology) Song et al., EMBO J 2008
• IRef Hprd Interaction: USP7 — DAXX (in vitro) Tang et al., Nat Cell Biol 2006
• IRef Hprd Interaction: USP7 — DAXX (in vivo) Tang et al., Nat Cell Biol 2006
• IRef Hprd Interaction: Complex of 28 proteins (in vivo) Song et al., EMBO J 2008
• IRef Intact Interaction: USP7 — DAXX (physical association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: USP7 — DAXX (colocalization, confocal microscopy) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: USP7 — DAXX (direct interaction, pull down) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: USP7 — DAXX (physical association, pull down) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 16 proteins (association, anti bait coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: Complex of USP7-RASSF1-DAXX (association, anti tag coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: Complex of USP7-MDM2-MDM2-MDM2-DAXX-DAXX-USP7-DAXX-USP7 (association, anti tag coimmunoprecipitation) Tang et al., Nat Cell Biol 2006

Text-mined interactions from Literome

Tang et al., Nat Cell Biol 2006 : Daxx simultaneously binds to Mdm2 and the deubiquitinase Hausp, and it mediates the stabilizing effect of Hausp on Mdm2
Tang et al., Biochem Biophys Res Commun 2010 : Daxx is reciprocally regulated by Mdm2 and Hausp ... We further demonstrate that Hausp critically controls the cellular level of Daxx most likely by inducing Daxx de-ubiquitination