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NOS1 — TPR

Text-mined interactions from Literome

Tost et al., J Cardiovasc Pharmacol 2003 : NO synthase (NOS) inhibition significantly increased blood pressure and total peripheral resistance (TPR) and decreased cardiac output in all groups of animals ... With the three degrees of volume expansion ( 20, 40, and 60 ml/kg ), the NOS inhibition increased the TPR from 30.7 R/kg +/- 1.90 to 73.6 R/kg +/- 5.00, from 20.7 R/kg +/- 1.43 to 66.7 R/kg +/- 3.88, and from 19.9 R/kg +/- 1.25 to 49.1 R/kg +/- 3.84 in the surgically less stressed animals and from 38.6 R/kg +/- 2.14 to 59.8 R/kg +/- 5.62, from 31.9 R/kg +/- 2.70 to 81.7 R/kg +/- 9.89, and from 29.1 R/kg +/- 2.49 to 91.1 R/kg +/- 6.36 in the surgically more stressed animals
Kiuchi et al., Circ Res 1993 (Cardiac Output, Low) : Inhibition of nitric oxide synthase increased TPR to a greater degree before HF ( +154 +/- 28 % [ control ] ) than after ( +80 +/- 22 % [ HF ] ) and eliminated the depressed responses to ACh but not to ISO