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PIK3CA — TLR3

Pathways - manually collected, often from reviews:

• KEGG Influenza A: TLR3 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  

Text-mined interactions from Literome

Guiducci et al., J Exp Med 2008 : We show that PI3K is activated by TLR stimulation in primary human pDCs and demonstrate, using specific inhibitors, that PI3K is required for type I IFN production by pDCs, both at the transcriptional and protein levels
Hodson et al., Adv Exp Med Biol 2009 : Although CD40, TLR and cytokines all activate PI3K the BCR seems especially dependent upon PI3K signalling
Dil et al., Mol Immunol 2009 : In this study we assess the role of p110 delta PI3K in TLR4, TLR9 , or TLR4+TLR9 mediated B cell responses
Shin et al., J Immunol 2009 : Consistent with this, B. burgdorferi activation of MyD88 or TLR3/TRIF signaling resulted in increased activity of PI3K
Schmid et al., Cancer Cell 2011 (Disease Progression...) : Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k? , a single convergent point promoting tumor inflammation and progression
Troutman et al., Cell cycle (Georgetown, Tex.) 2012 (Inflammation) : Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on TLR mediated activation of PI3K and its impact on regulating cellular processes