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Scanzello et al., Curr Opin Rheumatol 2008
(Chronic Disease...) :
TLRs are expressed and functional in the joint, and many proteases and cytokines that promote cartilage catabolism are dependent on nuclear factor-kappaB, a TLR activated transcription factor Sun et al., Circ Res 2009
:
TLR signaling via p38 led to phosphorylation and activation of the transcription factor Microphthalmia transcription factor, acting at E-box elements in the Ctsk promoter