We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to TAF1

TAF1 — TAF11

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Carter et al., J Biol Chem 1999 : The p38 kinase also phosphorylated TFIID ( TBP ) in vitro, and SB 203580 inhibited phosphorylation of TFIID ( TBP ) in vivo
Liu et al., Mol Cell Biol 1999 : To investigate the role of TFIIA in TFIID recruitment in vivo, we exploited a class of yeast TATA binding protein (TBP) mutants that is activation and DNA binding defective
Galasinski et al., Mol Cell Biol 2000 : Electrophoretic mobility shift assays and DNase I footprinting revealed that acetyl-CoA increased the affinity of the general transcription factor TFIID for promoter DNA in a TBP associated factor (TAF) dependent manner ... Electrophoretic mobility shift assays and DNase I footprinting revealed that acetyl-CoA increased the affinity of the general transcription factor TFIID for promoter DNA in a TBP associated factor (TAF) dependent manner ... Interestingly, acetyl-CoA also caused a conformational change in the TFIID-TFIIA-promoter complex as assessed by DNase I footprinting
Badarinarayana et al., Genetics 2000 : These genetic and physical interactions indicate that one role of the CCR4-NOT proteins is to inhibit functional TBP-DNA interactions, perhaps by interacting with and modulating the function of TFIID
Solow et al., J Biol Chem 2001 : Transcription factor IIA (TFIIA) is a positive acting general factor that contacts the TATA binding protein (TBP) and mediates an activator induced conformational change in the transcription factor IID (TFIID) complex
Lively et al., J Biol Chem 2001 : In support of this hypothesis, we found that c-Jun increased levels of TFIID-driven transcription in vitro when added at high concentrations to a DNA template lacking activator protein 1 (AP-1) sites
Shakkottai et al., J Biol Chem 2001 : By replacing Met ( 7 ) in the RXCQ motif of Lei with the shorter, unnatural, positively charged diaminobutanoic acid (Dab), we generated Lei-Dab ( 7 ), a selective SKCa2 inhibitor ( K ( d ) = 3.8 nm ) that interacts with residues in the external vestibule of the channel
Frontini et al., J Biol Chem 2002 : Using agarose-electrophoretic mobility shift assay we found that NF-Y increases the affinity of holo-TFIID for Ea in a CCAAT- and Inr dependent manner
Mencía et al., Mol Cell 2002 : TAFs are recruited to RP promoters even when TBP and other general transcription factors are not associated, suggesting that TFIID recruitment involves a direct activator-TAF interaction
Sanders et al., Mol Cell Biol 2002 : These interactions include association between TBP and the RSC chromatin remodeling complex, the TAF17p dependent association of the Swi6p transactivator protein with TFIID , and the identification of three novel subunits of the SAGA acetyltransferase complex, including a putative ubiquitin-specific protease component
Kubo et al., Neurosci Res 2002 : These precise patterns of neuronal alignment are regulated by an extracellular matrix protein Reelin , and binding of Reelin to its receptors induces tyrosine phosphorylation of the intracellular adaptor protein disabled 1 (Dab1)
Ainbinder et al., Mol Cell Biol 2002 : Here we report that even though NF-kappaB interacts directly with TAF(II)s, induction of NF-kappaB by tumor necrosis factor alpha (TNF-alpha) does not enhance TFIID recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters ... Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by tumor necrosis factor alpha (TNF-alpha) does not enhance TFIID recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters ... Here we report that even though NF-kappaB interacts directly with TAF(II)s , induction of NF-kappaB by tumor necrosis factor alpha (TNF-alpha) does not enhance TFIID recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters ... Here we report that even though NF-kappaB interacts directly with TAF(II)s, induction of NF-kappaB by tumor necrosis factor alpha (TNF-alpha) does not enhance TFIID recruitment and preinitiation complex formation on some NF-kappaB-responsive promoters
Hilton et al., J Biol Chem 2003 : These data suggest that a function of TAF is required for the interaction of TFIID with the cyclin D1 initiator
Mohan et al., Mol Cell Biol 2003 : TAF10 ( TAF(II)30 ) is necessary for TFIID stability and early embryogenesis in mice ... Thus, our results demonstrate that TAF10 is required for TFIID stability, cell cycle progression, and transcription in the early mouse embryo
Bock et al., J Biol Chem 2003 : Reelin signaling requires activation of Src family kinases as well as tyrosine phosphorylation of the intracellular adaptor protein Disabled-1 (Dab1)
Tatro et al., Cancer Res 1992 (Melanoma...) : DAB389-MSH inhibited binding of 125I-NDP-MSH to experimental murine B16-F1C23 melanoma metastasis tissue and to melanoma metastases of three patients ... DAB389-MSH inhibited binding of 125I-NDP-MSH to experimental murine B16-F1C23 melanoma metastasis tissue and to melanoma metastases of three patients ... In both mouse and human melanoma tissues, concentration-response relationships for DAB389-MSH mediated inhibition of 125I-NDP-MSH binding were parallel, and its maximal effects were comparable in magnitude, to those of NDP-MSH and alpha-MSH ... In both mouse and human melanoma tissues, concentration-response relationships for DAB389-MSH mediated inhibition of 125I-NDP-MSH binding were parallel, and its maximal effects were comparable in magnitude, to those of NDP-MSH and alpha-MSH
Lee et al., Mol Cell Biol 1992 : TFIIA induces conformational changes in TFIID via interactions with the basic repeat ... Taken together, these results suggest that TFIIA enhances TFIID binding to DNA by eliminating an otherwise inhibitory effect of the nonconserved N terminus of TFIID
Walker et al., J Biol Chem 2004 : We conclude that during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development and that TFIID and TLF may act together at certain promoters
Strasser et al., Mol Cell Biol 2004 : Reelin binding to apolipoprotein E receptor 2 (ApoER2) and very-low-density-lipoprotein receptor ( VLDLR ) leads to phosphorylation of disabled 1 (Dab1) , an adaptor protein which associates with the intracellular domains of both receptors
Fong et al., Genes Dev 1992 : The interaction of both cGATA-1 and TFIID at different times with the -30 GATA site is required for efficient beta-globin expression in vivo, and the GATA enhancer site can functionally replace the TATA element in the beta-globin promoter
Lenssen et al., Mol Cell Biol 2005 : The Ccr4-Not complex independently controls both Msn2 dependent transcriptional activation -- via a newly identified Glc7/Bud14 type I protein phosphatase module -- and TFIID promoter distribution ... Thus, increased activity of STRE genes in ccr4-not mutants may result from both altered general distribution of TFIID and unscheduled activation of Msn2
Prunier et al., J Biol Chem 2005 : Disabled-2 (Dab2) is required for transforming growth factor beta induced epithelial to mesenchymal transition ( EMT )
Sato et al., Glycobiology 2005 (Carcinoma, Embryonal) : Glucosylceramide synthase inhibitors ( d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [ d-PDMP ] and its analog ) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2) , suggesting the involvement of gangliosides in F9 cell differentiation
Mpari et al., J Integr Neurosci 2005 : Differential effects of two blockers of small conductance Ca2+ activated K+ channels, apamin and lei-Dab7 , on learning and memory in rats
Black et al., Mol Cell 2006 : Using purified proteins, we found that the Mediator regulates this assembly process by binding to p300 and TFIID
Tamura et al., EMBO J 1990 : Surprisingly, the brain TFIID activated transcription from the MBP core promoter while the liver TFIID did to a much lesser extent
Jiang et al., Oncogene 2008 (Carcinoma, Embryonal) : The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin
Diwakar et al., Biochem Biophys Res Commun 2008 (MAP Kinase Signaling System) : The adaptor phosphoprotein Disabled-2 (Dab2) is known to interact with the cytoplasmic tail of megalin and may be involved in albumin mediated MAPK signalling ... The adaptor phosphoprotein Disabled-2 (Dab2) is known to interact with the cytoplasmic tail of megalin and may be involved in albumin mediated MAPK signalling
Li et al., Cancer Lett 1991 (Carcinoma, Hepatocellular...) : The rates of ras activation were thus very low for both AAF- and 3'-Me-DAB induced rat HCCs , the results thus extending and confirming the findings indicating that ras activation in rat HCCs induced by various type of carcinogens is infrequent
Zhang et al., J Biol Chem 2008 : Thus, RNR3 is dependent upon both TFIID and SAGA, two complexes that deliver TATA binding protein (TBP) to promoters ... Thus, RNR3 is dependent upon both TFIID and SAGA, two complexes that deliver TATA binding protein (TBP) to promoters
Zhu et al., New Biol 1991 : These results suggest that SRF may affect TFIID via a cofactor or coactivator
Takahashi et al., J Biol Chem 2009 : These findings identify an unexpected role for the HNF4alpha DNA binding domain in mediating key regulatory interactions and provide new insights into the roles of HNF4alpha and TFIID in RNA polymerase II transcription
Elmlund et al., Structure 2009 : The general transcription factor IID (TFIID) is required for initiation of RNA polymerase II-dependent transcription at many eukaryotic promoters
Phillips et al., Cell Immunol 2010 (Encephalomyelitis, Autoimmune, Experimental...) : DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions ... DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions ... DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions ... DAB ( 389 ) IL-2 also significantly reduced the number of CD4 ( + ), CD8 ( + ), CD25 ( + ), TCRgammadelta ( + ) phenotype and CD11b ( + ) macrophages/microglia within spinal cord lesions
Matsumoto et al., FEBS Lett 1991 : From the results of DNase I protection experiments, it was indicated that NFI bound to its binding site in the Ad replication origin prevents TFIID from proper binding to the adjacent AT-rich region and consequently represses the transcription
Medvedeva et al., Tsitologiia 1978 : The hepatospecific carcinogen 4-dimethylaminoazobenzene (DAB) , applied as a single interperitoneal injection, induced no changes in the activity of mitochondrial and cytoplasmic malate-dehydrogenase in the rat liver
Hoey et al., Cell 1990 : Partially purified TFIID from Drosophila cells mediates activation by the transcription factor Sp1
Choukrallah et al., Nucleic Acids Res 2012 : Transcriptome and ChIP-seq analyses show that loss of B-TFIID does not generally alter gene expression or genomic distribution of TBP, but positively or negatively affects TBP and/or Pol II recruitment to a subset of promoters
Chen et al., J Biol Chem 2012 : In addition, both reelin and apoE3 significantly increased phosphorylated disabled-1 (Dab1) , phosphatidylinositol 3-kinase (PI3K), protein kinase C? ( PKC? ), and specificity protein 1 (Sp1) ... In addition, both reelin and apoE3 significantly increased phosphorylated disabled-1 (Dab1) , phosphatidylinositol 3-kinase (PI3K), protein kinase C? ( PKC? ), and specificity protein 1 (Sp1)
Maldonado et al., Mol Cell Biol 1990 : Binding of the human and yeast TFIID to the TATA motif was stimulated by TFIIA
Meisterernst et al., Proc Natl Acad Sci U S A 1990 : Recombinant yeast TFIID , a general transcription factor, mediates activation by the gene-specific factor USF in a chromatin assembly assay
Kambadur et al., Proc Natl Acad Sci U S A 1990 : We have studied the role of TFIID in the transcription of the yeast metallothionein gene, which is regulated by the copper dependent activator protein ACE1 ... Both basal and induced transcription of the metallothionein gene require TFIID and a functional TATA binding site
Scheer et al., J Biol Chem 2012 : TFIID TAF6-TAF9 complex formation involves the HEAT repeat containing C-terminal domain of TAF6 and is modulated by TAF5 protein
Lehmann et al., J Biol Chem 2012 : Immobilized template experiments using purified PRC1, transcription factor II D (TFIID), and Mediator indicate that PRC1 blocks the recruitment of Mediator, but not TFIID
Wagner et al., J Virol 2013 : Affinity purification experiments demonstrated that d3-10 ICP4 was not found in complexes with components of TFIID and mediator, suggesting that the defect in RNA polymerase II (Pol II) recruitment was the result of ablated interactions between d3-10 and TFIID and mediator
Workman et al., EMBO J 1990 : Function of USF during nucleosome assembly required the simultaneous presence of the TATA box binding protein TFIID
Perez et al., J Virol 2013 (Herpesviridae Infections) : Our results suggest that the interactions of IE3 with IE3AM and with TBP stabilize the TFIID complex at the M112-113 promoter such that M112-113 gene expression can be activated and/or enhanced
Lauberth et al., Cell 2013 : We demonstrate that H3K4me3-TAF3 interactions direct global TFIID recruitment to active genes, some of which are p53 targets ... Further analyses show that ( 1 ) H3K4me3 enhances p53 dependent transcription by stimulating preinitiation complex (PIC) formation ; ( 2 ) H3K4me3, through TAF3 interactions, can act either independently or cooperatively with the TATA box to direct PIC formation and transcription ; and ( 3 ) H3K4me3-TAF3/TFIID interactions regulate gene-selective functions of p53 in response to genotoxic stress
Malik et al., Mol Cell Biol 2013 : Intriguingly, while GAL10 antisense transcription is dependent on TFIID , its sense transcription does not require TFIID
Martinez-Pacheco et al., Arch Microbiol 1989 : Diamino butanone (DAB) , a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenomenon
Horikoshi et al., Cell 1988 : These results indicate that TFIID is a direct target for ATF , that these interactions facilitate assembly of a complete preinitiation complex, and that the role of ATF might be transient
Fiala et al., J Natl Cancer Inst 1980 (Hyperplasia...) : We concluded that DSF 1 ) did not interfere with 3'-Me-DAB induced proliferation of preneoplastic cells and the increase in GT-ase associated with this reversible adaptation to the influx of 3'-Me-DAB ; and 2 ) inhibited malignant transformation and, consequently, prevented the formation and proliferation of neoplastic cells and the increase in constitutive GT-ase related to neoplasia
Dent et al., Carcinogenesis 1982 (Liver Neoplasms...) : Both DEN and DAB caused increases in epoxide hydrolase but classical sigmoidal dose-response curves were not obtained
Ramadan et al., Cell Immunol 1995 (Granuloma...) : DAB389IL-2 suppressed IL-2 , lectin mitogen ( Con A ), and soluble Schistosoma mansoni egg antigen induced lymphocyte proliferation and in vitro granuloma formation
Ozer et al., Genes Dev 1994 : Recombinant TFIIA mediated the stimulation of TFIID binding to the TATA region and downstream promoter sequences by the Zta transcriptional activator
Parvin et al., J Biol Chem 1994 : As had been observed for the TATA binding protein (TBP) subunit ( Parvin and Sharp, 1993 ), transcription from the IgH promoter minimally requires TFIID activity plus TFIIB and RNA polymerase II
Kretzschmar et al., Mol Cell Biol 1994 : In the presence of native TFIID and other general factors, PC2 was necessary and sufficient for activation by GAL4-AH
Goodrich et al., Cell 1993 : Enhancement of RNA polymerase II transcription by the viral transactivator VP16 requires the TFIID complex , which consists of the TATA binding protein (TBP) and TBP associated factors (TAFs)
Weinzierl et al., EMBO J 1993 : Regulation of transcription initiation by RNA polymerase II requires TFIID , a multisubunit complex composed of the TATA binding protein (TBP) and at least seven tightly associated factors ( TAFs )
Leibham et al., Mol Cell Biol 1994 : Transcription of the minimal XMyoDa promoter in nonmuscle cells was activated by expression of Xenopus MEF2 ( XMEF2 ) and required binding of both MEF2 and TFIID to the TATA motif
Kokubo et al., J Biol Chem 1993 : Immobilized TFIID mediated not only basal transcription but transcriptional activation by upstream stimulatory factor ( USF )
Chen et al., Genes Dev 1993 : Surprisingly, both TBP and TFIID also stimulate p53 binding to DNA containing a specific p53 binding site but lacking a TATA box
Collart et al., EMBO J 1993 : Both TC and TR support basal HIS3 transcription and require the TATA binding protein TFIID , but only TR responds to transcriptional activation by GCN4 and GAL4
Dubrovskaya et al., EMBO J 1996 : We demonstrate that the hTAFII100-TFIIF interaction supports pre-initiation complex formation in the presence of TFIID
Caron et al., Proc Natl Acad Sci U S A 1997 : From these observations we propose that transcriptional activation by Tax involves multiple interactions with TFIID via its TBP and hTAF ( II ) 28 subunits
Bousvaros et al., Dig Dis Sci 1997 : DAB389IL-2 ( 10 ( -12 ) M ) also significantly reduced the numbers of activated helper T cells and IFN-gamma levels in 24-hr cultures
Emami et al., Genes Dev 1997 : Interestingly, however, recombinant TFIIA strongly and selectively enhanced TFIID binding to the TATA-Inr promoter, with little effect on binding to the TATA promoter
Guermah et al., Mol Cell Biol 1998 : Transcriptional activation by NF-kappaB and Sp1 requires both TFIID and the USA fraction ... Transcriptional activation by NF-kappaB and Sp1 requires both TFIID and the USA fraction
Kotani et al., J Biol Chem 1998 : In these respects, the impact of yTANDII mutations on cell growth paralleled their effects on TBP binding in vitro, strongly suggesting that the yTAFII145-TBP interaction and its negative effects on TFIID binding to core promoters are physiologically important
Lambert de Rouvroit et al., Biochem Pharmacol 1998 : The response of cortical plate cells to reelin requires the tyrosine kinase adaptor disabled-1 (Dab1)