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SFTPC — SMN1

Text-mined interactions from Literome

Jeon et al., J Cell Sci 2006 : Pretreatment of the cells with pertussis toxin or U0126, an MEK inhibitor, markedly attenuated the SPC induced expression of beta-SMA and delayed phosphorylation of Smad2, suggesting that the Gi/o-ERK pathway is involved in the increased expression of alpha-SMA through induction of delayed Smad2 activation ... In addition, SPC increased secretion of TGF-beta1 through an ERK dependent pathway, and the SPC induced expression of alpha-SMA and delayed phosphorylation of Smad2 were blocked by SB-431542, a TGF-beta type I receptor kinase inhibitor, or anti-TGF-beta1 neutralizing antibody ... Silencing of Smad2 expression with small interfering RNA ( siRNA ) abrogated the SPC induced expression of alpha-SMA ... siRNA mediated depletion of SRF or myocardin abolished the alpha-SMA expression induced by SPC or TGF-beta
Kim et al., Exp Mol Med 2012 : In the present study, we examined the effects of simvastatin on the SPC induced a-SMA expression and Smad2 phosphorylation in hASCs ... Simvastatin inhibited the SPC induced a-SMA expression and sustained phosphorylation of Smad2 in hASCs ... The SPC induced a-SMA expression and Smad2 phosphorylation were abrogated by pretreatment of the cells with the Rho kinase inhibitor Y27632 or overexpression of a dominant negative RhoA mutant