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Yang et al., Cancer Sci 2009
(Retinal Neoplasms...) :
It has been reported that
PEDF can
induce neuronal differentiation of retinoblastoma cells ; however, its anti-angiogenic potential for inhibition of retinoblastoma growth in vivo has not been elucidated
Sugita et al., J Neurosci Res 1997
:
Pigment epithelium derived factor (PEDF) , a neurotrophic agent first identified in conditioned medium from cultured human retinal pigment epithelial cells,
induces neuronal differentiation with neurite outgrowth in Y-79 retinoblastoma cells and has a neurotrophic survival effect on cerebellar granule cells in culture