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RUNX1 — ZEB2
Text-mined interactions from Literome
Izutsu et al., Oncogene 2002
(Leukemia, Myeloid) :
Here, we demonstrate that AML1/Evi-1 interacts with CtBP in SKH1 cells, a leukemic cell line which endogenously overexpresses AML1/Evi-1 and that
AML1/Evi-1 requires the interaction with
CtBP to repress AML1 induced transactivation
Chan et al., Blood 2005
(Myelodysplastic Syndromes...) :
These results suggest a central
role for
CtBP in
AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia