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Sancak et al., Science 2008
:
Conversely, expression of a guanosine diphosphate bound Rag mutant prevented stimulation of mTORC1 by amino acids
Sancak et al., Cell 2010
(MAP Kinase Signaling System) :
Thus, Rag-Ragulator mediated translocation of mTORC1 to lysosomal membranes is the key event in amino acid signaling to mTORC1
Settembre et al., EMBO J 2012
:
Interestingly, the Rag GTPase complex, which senses lysosomal amino acids and activates mTORC1 , is both necessary and sufficient to regulate starvation- and stress induced nuclear translocation of TFEB
Durán et al., Mol Cell 2012
:
Constitutively active Rag heterodimer activated mTORC1 in the absence of glutaminolysis