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FOXP3 — PTBP2

Text-mined interactions from Literome

Buckland et al., Am J Transplant 2006 : Blocking ILT-3 or IL-12 does not diminish the capacity of these DCs to induce regulation or Foxp3 expression on the regulatory T cells
Luo et al., Proc Natl Acad Sci U S A 2007 (Diabetes Mellitus, Type 1) : Here we show that beta-cell peptide pulsed dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively induce CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the presence of TGF-beta1 ... These results indicate a role for DCs in the induction of antigen-specific CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells that can inhibit fully developed autoimmunity in a nonlymphopoenic host, providing an important potential strategy for immunotherapy in patients with autoimmune diabetes
Matsumura et al., J Immunol 2007 : In this study, we demonstrated that suppressors of cytokine signaling (SOCS)-3-deficient DCs have a strong potential as Foxp3 ( + ) T cell inducing tolerogenic DCs
Westendorf et al., Gut 2009 (Inflammatory Bowel Diseases) : Although gut associated DCs can induce antigen-specific CD4 ( + ) Foxp3 ( + ) T cell proliferation, in vivo depletion of DCs did not preclude proliferation of these cells
Ganesh et al., Int Immunol 2009 (Thyroiditis, Autoimmune) : Collectively, our results show that GM-CSF renders CD8a- DCs tolerogenic, and these DCs induce Foxp3+ and IL-10+ Tregs
Silva-Campa et al., Virology 2009 (Porcine Reproductive and Respiratory Syndrome) : Our results showed that PRRSV infected DCs significantly increased Foxp3 ( + ) CD25 ( + ) T cells, an effect that was reversible by IFN-alpha treatment, and this outcome was reproducible using two distinct PRRSV strains
Brenk et al., J Immunol 2009 : Moreover, ILT3 ( high ) ILT4 ( high ) DCs lead to the induction of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T regulatory cells with suppressive activity from CD4 ( + ) CD25 ( - ) T cells
Kushwah et al., J Immunol 2009 : We have shown that in vitro culture of apoptotic DCs with immature DCs, results in their uptake by immature DCs, which subsequently turn into tolerogenic DCs , which then secrete TGF-beta1 and induce Foxp3 ( + ) regulatory T cells ( T ( regs ) )
Liu et al., J Cell Mol Med 2009 : GXM pulsed DCs increased the expression of forkhead box P3 (Foxp3) in naïve human CD4 ( + ) CD25 ( - ) T cells via activating Fc gamma receptor IIb and activator protein-1 and promoting the expression of transforming growth factor beta in dendritic cells
Pothoven et al., Am J Transplant 2010 : This work addresses whether rapamycin conditioned donor DCs could effectively induce CD4 ( + ) CD25 ( + ) Foxp3 ( + ) Tregs ( iTregs ) in cell cultures with alloantigen specificities, and whether such in vitro differentiated CD4 ( + ) CD25 ( + ) Foxp3 ( + ) iTregs could effectively control acute rejection in allogeneic islet transplantation
Fukaya et al., Methods Mol Biol 2011 : Furthermore, antigen-specific generation of CD4 ( + ) Foxp3 ( + ) iT ( regs ) required the function of CD11 ( + ) DCs under steady-state conditions, whereas such conversion was severely abolished under inflammatory conditions
Worthington et al., Gastroenterology 2011 : DCs that lack expression of integrin avß8 had reduced ability to activate latent TGF-ß and induce Foxp3 ( + ) Tregs in vitro and in vivo
Agace et al., Trends Immunol 2012 : Small intestine ( SI ) CD103 ( + ) DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and a4ß7 on responding T and B cells, and enhance forkhead box P3 ( + ) T regulatory and IgA plasma cell differentiation in vitro
Zhao et al., Eur J Cancer 2012 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : CML-MSC-DCs derived TGF-ß1 was largely responsible for the increase in CD4+CD25+Foxp3+Tregs based on knockdown studies
Cecere et al., Vet Microbiol 2012 (Coinfection...) : DCs infected with PCV2 significantly increased CD4 ( + ) CD25 ( + ) FoxP3 ( + ) T ( regs ) ( p < 0.05 ) and DCs co-infected with PRRSV and PCV2 induced significantly higher numbers of T ( regs ) than with PCV2 alone ( p < 0.05 )
Ramos et al., J Leukoc Biol 2012 (Breast Neoplasms) : In cancer, DCs may play a dysfunctional role in the induction of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) Tregs, contributing to immune evasion
Cavatorta et al., Clinical and vaccine immunology : CVI 2012 : Upon stimulation with DCs or the mitogen concanavalin A, a subset of the proliferating T cells expresses the regulatory T-cell ( Treg ) transcription factor FoxP3
Olivar et al., J Immunol 2013 (Inflammation) : Moreover, C4BP ( ß ( - ) ) -treated DCs failed to enhance allogeneic T cell proliferation, impairing IFN-? production in these cells and, conversely, promoting CD4 ( + ) CD127 ( low/neg ) CD25 ( high ) Foxp3 ( + ) T cells
Khare et al., J Immunol 2013 : CD103 ( + ) DCs from tolerized mice efficiently induced Foxp3 in cocultured naive CD4 ( + ) T cells but pDCs and lung macrophages failed to do so
Tsai et al., J Immunol 2013 (Diabetes Mellitus, Experimental) : We expressed an I-Ea ( kloxP ) transgene in NOD mice and used cell type-specific I-E ablation to show that I-E expressing DCs , but not B cells, promote the generation of autoreactive CD4 ( + ) Foxp3 ( + ) regulatory T cells ( Tregs ) and their accumulation in the pancreas draining lymph nodes
Matsumoto et al., J Immunol 2013 (Disease Models, Animal...) : The PKCI treated DCs had a semimature phenotype, showing high production of IL-10, and efficiently induced IL-10 producing T cells and functional Foxp3 ( + ) regulatory T cells from naive CD4 ( + ) T cells, thus eliciting a strong immunosuppressive function