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PPP2R2B — PRKAA2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Liangpunsakul et al., Am J Physiol Gastrointest Liver Physiol 2008
(Liver Neoplasms, Experimental) :
More importantly, the inhibitory effects of ethanol on H ( 2 ) O ( 2 ) -induced
AMPK phosphorylation were
attenuated by the presence of the
PP2A inhibitor, okadaic acid, or PP2A siRNA
Liangpunsakul et al., Am J Physiol Gastrointest Liver Physiol 2010
:
These changes in intracellular ceramide concentrations and
PP2A activity correlated with the time course over which ethanol
inhibited AMPK phosphorylation
Wang et al., PloS one 2010
:
These results demonstrate that during heat shock response,
PP2A mediated
AMPK inhibition upregulates HSP70 expression at least partially through stabilizing its mRNA, which suggests a novel mechanism for HSP induction under stress
Park et al., Cell Calcium 2013
:
More importantly, the inhibitory effect of caffeine on
AMPK activity was
attenuated by the
PP2A inhibitor, calyculin A or siRNA induced knockdown of PP2A
Yu et al., J Biol Chem 2013
(Carcinoma, Hepatocellular...) :
Up-regulating PP2A activity suppressed nilotinib induced AMPK phosphorylation and autophagy, suggesting that
PP2A mediates the effect of nilotinib on
AMPK phosphorylation and autophagy ... Our data indicate that nilotinib induced
AMPK activation is
mediated by
PP2A , and AMPK activation and subsequent autophagy might be a major mechanism of action of nilotinib ... Together, our results reveal that nilotinib induces autophagy, but not apoptosis in HCC, and that the autophagy inducing activity is associated with
PP2A regulated
AMPK phosphorylation