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FOXO1 — PRKAA2

Text-mined interactions from Literome

Greer et al., Curr Biol 2007 : Lastly, we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites, suggesting a possible direct mechanism of regulation of FOXO/DAF-16 by AMPK
Dixit et al., Cardiovasc Res 2008 : Moreover, as the AMPK dependent phosphorylation and degradation of FoxO1a attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha, this kinase may be a useful target to prevent the progression of vascular diseases
Nystrom et al., International journal of clinical and experimental medicine 2008 : Our data indicate FoxO mRNA expression is down-regulated by AMPK activation and energy depletion in cultured myotubes, but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions
Greer et al., Ann N Y Acad Sci 2009 : AMPK phosphorylation enhances FoxO transcriptional activity, leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism
Reiter et al., Endocrinology 2010 : EGCG induced nuclear exclusion of FOXO1 , FOXO1 binding to the hET-1 promoter, and reduction of ET-1 expression was partially inhibited by the AMPK inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1 ... We conclude that EGCG decreases ET-1 expression and secretion from endothelial cells, in part, via Akt- and AMPK stimulated FOXO1 regulation of the ET-1 promoter
Chen et al., Acta Pharmacol Sin 2010 (Cardiomegaly) : Furthermore, AMPK activation increased the activity of transcription factor FOXO1 and up-regulated downstream atrogene MuRF1 mRNA and protein expression
Chen et al., Nan Fang Yi Ke Da Xue Xue Bao 2010 : Activated AMPK significantly inhibited the phosphorylation of FOXO1 and increased MuRF1 protein expression
Vadlakonda et al., Frontiers in oncology 2013 : Depletion of energy leads to inactivation of mTORC1, activation of AMPK , FoxO , and promotes constitution of mTORC2 that leads to phosphorylation of Akt S473