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APPL1 — PRKAA2

Text-mined interactions from Literome

Cheng et al., Diabetes 2007 : Suppression of APPL1 expression by RNA interference significantly attenuated adiponectin induced phosphorylation of AMP activated protein kinase (AMPK) at Thr ( 172 ) and eNOS at Ser ( 1177 ), and the complex formation between eNOS and heat shock protein 90, resulting in a marked reduction of NO production
Chandrasekar et al., J Biol Chem 2008 (Inflammation) : Adiponectin blocks interleukin-18 mediated endothelial cell death via APPL1 dependent AMP activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression ... Pretreatment with adiponectin stimulated APPL1 dependent AMPK activation, reversed Akt inhibition in a phosphatidylinositol 3-kinase dependent manner, blocked IKK-NF-kappaB-PTEN signaling, reduced caspase-3 activity, blocked Bax translocation, and inhibited endothelial cell death
Zhou et al., J Biol Chem 2009 : The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin induced AMP activated protein kinase (AMPK) activation in muscle, yet the underlying molecular mechanism remains unknown
Holmes et al., Diabetologia 2011 (Diabetes Mellitus, Type 2...) : Improvements in hyperglycaemia and hypoadiponectinaemia following weight loss are associated with reduced skeletal muscle APPL1 , and increased plasma adiponectin levels and muscle AMPK phosphorylation