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MUC1 — PPARG

Text-mined interactions from Literome

Slomiany et al., IUBMB Life 2003 (Helicobacter Infections) : Using gastric mucosal cells in culture, we show that activation of PPARgamma with a specific synthetic agonist, ciglitazone, prevents in a dose dependent fashion ( up to 90.2 % ) the LPS induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in the LPS induced apoptosis ( 72.4 % ), NO generation ( 80.1 % ), and the expression of NOS-2 activity ( 90 % )
Slomiany et al., IUBMB Life 2004 : We show that activation of PPARgamma with a specific agonist, ciglitazone, prevents the LPS induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in apoptosis, caspase-3 activity and NO generation
Slomiany et al., Inflammopharmacology 2004 : Using gastric mucosal cells in culture, we show that activation of PPARgamma with a specific agonist, ciglitazone, prevents the LPS induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in apoptosis, caspase-3 activity and NO generation
Shalom-Barak et al., Mol Cell Biol 2004 : Muc1 promoter is activated strongly and specifically by liganded PPARgamma but not PPARalpha or PPARdelta ... A PPAR binding site ( DR1 ) in the proximal Muc1 promoter acts as a basal silencer in the absence of PPARgamma, and its cooperation with a composite upstream enhancer element is both necessary and sufficient for PPARgamma dependent induction of Muc1 ... Last, variably penetrant maternal blood sinus dilation in Muc1-deficient placentas suggests that Muc1 regulation by PPARgamma contributes to normal placental development but also that the essential functions of PPARgamma in the organ are mediated by other targets
Lee et al., Am J Physiol Lung Cell Mol Physiol 2006 (Carcinoma, Mucoepidermoid...) : However, no data are available on the role of PPAR-gamma in smoke induced mucin production ... In this study, we investigated the effect of PPAR-gamma agonist ( rosiglitazone ) on smoke induced mucin production in NCI-H292 cells