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HDAC3 — PPARG

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of retinoblastoma protein: RB1/PPARG/HDAC3 complex (RB1-PPARG-HDAC3) → HDAC3 (HDAC3) (modification, collaborate) Fajas et al., Dev Cell 2002*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/PPARG/HDAC3 complex (RB1-PPARG-HDAC3) → RB1/PPARG complex (RB1-PPARG) (modification, collaborate)
  Fajas et al., Dev Cell 2002*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: HDAC3 (HDAC3) → RB1/PPARG complex (RB1-PPARG) (modification, collaborate)
  Fajas et al., Dev Cell 2002*
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: HDAC3 → PPARG (reaction) Gelman et al., J Biol Chem 1999, Farmer et al., Cell Metab 2006, Lambe et al., Eur J Biochem 1996, Lemberger et al., Annu Rev Cell Dev Biol 1996, Mukherjee et al., J Biol Chem 1997
• Reactome Reaction: HDAC3 → PPARG (indirect_complex) Farmer et al., Cell Metab 2006, Lemberger et al., Annu Rev Cell Dev Biol 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC3 — PPARG (physical association, affinity chromatography technology) Annicotte et al., Mol Cell Biol 2006*
• IRef Biogrid Interaction: HDAC3 — PPARG (colocalization, imaging technique) Annicotte et al., Mol Cell Biol 2006*
• IRef Biogrid Interaction: HDAC3 — PPARG (direct interaction, pull down) Fajas et al., Dev Cell 2002*
• IRef Biogrid Interaction: HDAC3 — PPARG (physical association, affinity chromatography technology) Fajas et al., Dev Cell 2002*
• IRef Biogrid Interaction: HDAC3 — PPARG (direct interaction, pull down) Franco et al., Mol Cell Endocrinol 2003

Text-mined interactions from Literome

Fajas et al., Dev Cell 2002 : The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation
Akaike et al., Mol Cell Biol 2004 : Furthermore, association of ERK5a and PPARgamma1 disrupted the interaction of SMRT and PPARgamma1, thereby inducing PPARgamma activation
Gao et al., J Biol Chem 2006 : Rather, these results suggest that IkappaBalpha dependent nuclear translocation of HDAC3 is responsible for PPARgamma inhibition by TNF-alpha
Knutson et al., EMBO J 2008 (Hypertrophy...) : Loss of Hdac3 also increased the levels of Ppar gamma2 , and treatment of these mice with a Ppar gamma antagonist partially reversed the lipid accumulation in the liver
Lai et al., Biochim Biophys Acta 2008 : Taken together, we suggest that suCEBPD/HDAC1/HDAC3 complex inactivates PPARG2 transcription, and the induction of CEBPD expression transiently activates PPARG2 transcription which is involved in adipocyte-like lipogenesis in HepG2 cells