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ADORA1 — PIK3CA

Text-mined interactions from Literome

Carini et al., Gastroenterology 2004 (Reperfusion Injury) : PI3K activation in preconditioned hepatocytes required the stimulation of adenosine A 2A receptors and was mimicked by adenosine A 2A receptors agonist CGS21680 ... This suggested that PKA phosphorylated adenosine A 2A receptors may activate PI3K by coupling it with Galphai-protein through Src ... PI3K is activated following hepatocyte hypoxic preconditioning by the combined stimulation of adenosine A 2A receptors, PKA, Galphai protein, and Src
Button et al., Exp Physiol 2005 : Phosphatidylinositol 3-kinase and ERK1/2 are not involved in adenosine A1 , A2A or A3 receptor mediated preconditioning in rat ventricle strips
Huang et al., Biochem J 2006 : Somatostatin acting via G ( i ) 1-coupled sstr3 receptor, DPDPE ( [ D-Pen2,D-Pen5 ] enkephalin ; where Pen is penicillamine ) acting via G ( i ) 2-coupled delta-opioid receptors, and cyclopentyl adenosine acting via G ( i ) 3-coupled adenosine A1 receptors preferentially activated PI3K ( phosphoinositide 3-kinase ) and ILK ( integrin linked kinase ), whereas ACh ( acetylcholine ) acting via G ( i ) 3-coupled M2 receptors preferentially activated PI3K, Cdc42 ( cell division cycle 42 ) /Rac1, PAK1 ( p21 activated kinase 1 ) and p38 MAPK ( mitogen activated protein kinase )