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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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NUP214 — NUP62

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

D'Souza et al., Neuroscience 1999 : In the caudate-putamen, morphine induced c-Fos expression was significantly reduced by NPC-17742 ( 30 min before morphine ) in males and completely blocked in females
Chen et al., Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 1996 (Nasopharyngeal Neoplasms) : The major antigenic determinants for NPC serum IgA response were between amino acid ( aa ) 390 to aa 459 when different portions of EBNA-1 were used as antigens
Claudio et al., Cancer Res 2000 (Nasopharyngeal Neoplasms) : Although the involvement of p53 and of the retinoblastoma gene ( RB/p105 ) in NPC has been well studied, there is paucity of mutational data regarding the retinoblastoma related gene RB2/p130 in primary tumors and particularly in NPC
Kulapaditharom et al., J Med Assoc Thai 1999 (Nasopharyngeal Neoplasms...) : Our study demonstrated that HpD-PDT could effectively control locally recurrent or residual NPC at T1-T2 stages and offered good palliation for more advances
Sung et al., Int J Cancer 2000 (Epstein-Barr Virus Infections...) : In this study, analysis of FHIT gene structure and transcription in primary tumors did not support a role for FHIT in NPC
Du et al., Zhonghua Er Bi Yan Hou Ke Za Zhi 1997 (Carcinoma, Squamous Cell...) : The results indicate that PCNA affects proliferation activity of NPC and there are bright prospects for their application in the clinic
Jan et al., Chin J Physiol 2000 (Carcinoma, Transitional Cell...) : This report demonstrates that NPC-15199 [ ( N- ( 9-fluorenylmethoxycarbonyl ) L-leucine ) ], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer ( BFTC ) cells ... In Ca2+-free medium, pretreatment with 1 mM NPC-15199 abolished the [ Ca2+ ] i increase induced by 1 microM thapsigargin ( an endoplasmic reticulum Ca2+ pump inhibitor ) ; and after pretreatment with thapsigargin, NPC-15199 induced Ca2+ release was dramatically inhibited ... Together, the findings suggest that in BFTC bladder cancer cells, NPC-15199 induced Ca2+ release from the endoplasmic reticulum and activating Ca2+ entry
Zhou et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 1998 (Carcinoma, Squamous Cell...) : To evaluate the role of nm23-H1 and p53 protein expression in Nasopharyngeal Carcinoma (NPC) , the S-P immunohistochemical method was used to detect the expression of nm23-H1 and p53 protein in 125 cases of NPC ... To evaluate the role of nm23-H1 and p53 protein expression in Nasopharyngeal Carcinoma (NPC) , the S-P immunohistochemical method was used to detect the expression of nm23-H1 and p53 protein in 125 cases of NPC
Marelli et al., J Cell Biol 2001 : We also demonstrated that the targeting of excess Nup53p to the NPC and its specific association with intranuclear membranes were dependent on the karyopherin Kap121p and the nucleoporin Nup170p
Giachelli et al., Am J Kidney Dis 2001 (Calcinosis...) : The effects of elevated Pi on HSMC were mediated by a sodium dependent phosphate cotransporter ( NPC ), as indicated by the ability of the specific NPC inhibitor, phosphonoformic acid ( PFA ), to dose-dependently inhibit Pi-induced calcium deposition as well as osteocalcin and Cbfa-1 gene expression
Qiu et al., Zhonghua Zhong Liu Za Zhi 2000 (Nasopharyngeal Neoplasms) : To investigate the possible pathogenetic role of cytokeratin 13 (CK13) gene expression in human nasopharyngeal carcinoma (NPC)
Iouk et al., J Cell Biol 2002 : The association of the Mad1p-Mad2p complex with the NPC requires Mad1p and is mediated in part by Nup53p
Hwang et al., Cancer Lett 2003 (Carcinoma...) : To clarify the roles of p27 and c-myc in nasopharyngeal carcinoma (NPC) , we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC
Lei et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 1999 (Nasopharyngeal Neoplasms) : To evaluate the roles of p16, p21 and p53 protein expression in nasopharyngeal carcinoma (NPC) ... To evaluate the roles of p16, p21 and p53 protein expression in nasopharyngeal carcinoma (NPC)
Liu et al., Chin J Cancer 2003 (Carcinoma, Squamous Cell...) : In order to investigate the involvement of SEMA3B and SEMA3F in NPC , the authors examined both mutation and expression of these two genes in NPC ... In order to investigate the involvement of SEMA3B and SEMA3F in NPC , the authors examined both mutation and expression of these two genes in NPC
Jan et al., Life Sci 2003 (Calcium Signaling...) : Effect of NPC-14686 ( Fmoc-L-homophenylalanine ) on intracellular Ca2+ levels in human hepatoma cells
Oh et al., Brain Res 2003 (Parkinsonian Disorders) : However, in rats that received levodopa treatment for 21 days without the gene transfer, intrastriatal NPC-15437 had no effect on the response shortening or on GluR1 S831 phosphorylation
Jan et al., Chin J Physiol 2002 : Effect of NPC-15199 on Ca2+ levels in renal tubular cells ... In Madin-Darby canine kidney ( MDCK ) cells, effect of NPC-15199 on intracellular Ca2+ concentration ([Ca2+]i) was investigated by using fura-2 ... These results suggest that NPC-15199 rapidly increases [ Ca2+ ] i by stimulating both extracellular Ca2+ influx and intracellular Ca2+ release via as yet unidentified mechanism ( s )
De Souza et al., Curr Biol 2004 : Mitotic modification of the NPC requires NIMA and Cdk1 kinase activation
Scott et al., Shock 2005 : These data indicate that functional TLR4 and CD14 are required for NPC production of cytokines and that at least one of the critical components from hepatocytes is LBP ... These data indicate that functional TLR4 and CD14 are required for NPC production of cytokines and that at least one of the critical components from hepatocytes is LBP
Huang et al., Life Sci 2006 (Calcium Signaling...) : The effect of NPC-14686 , a potential anti-inflammatory drug, on cytosolic free Ca2+ levels ( [ Ca2+ ] i ) and growth in PC3 human prostate cancer cells was examined by using fura-2 as a fluorescent Ca2+ indicator and WST-1 as a fluorescent growth dye ... NPC-14686 at concentrations above 10 microM increased [Ca2+ ] i in a concentration dependent manner with an EC50 value of 100 microM ... Pretreatment with 1 microM thapsigargin ( an endoplasmic reticulum Ca2+ pump inhibitor ) to deplete the endoplasmic reticulum Ca2+ nearly abolished 200 microM NPC-14686 induced Ca2+ release ; and conversely pretreatment with NPC-14686 completely inhibited thapsigargin induced Ca2+ release ... The Ca2+ release induced by 200 microM NPC-14686 was not affected by inhibiting phospholipase C with 2 microM U73122
Zhang et al., Hua Xi Yi Ke Da Xue Xue Bao 1991 : Unlabeled purified apolipoprotein CIII-1, but apoAI , CI, CII, could effectively inhibit 125I labeled VLDL binding to NPC ... Unlabeled purified apolipoprotein CIII-1 , but apoAI, CI, CII, could effectively inhibit 125I labeled VLDL binding to NPC
Wu et al., Clin Cancer Res 2006 (Nasopharyngeal Neoplasms) : The aims of this work were to investigate the antitumor effect of IFNgamma gene transfer on human nasopharyngeal carcinoma (NPC) and to assess the potential of minicircle vector for antitumor gene therapy
Ramos et al., Brain Res Bull 2007 : VEGF and BDNF are proposed as key mediators of DES induced NPC mitotic response
Sullivan et al., Mol Pharmacol 1992 : Stimulation of PKC alpha by phosphatidylserine was competitively inhibited by NPC 15437 ( Ki = 12 +/- 4 microM )
Zheng et al., Cell Mol Immunol 2007 (Carcinoma...) : Our studies focused on the role of LMP1 in NPC , and showed that LMP1 triggers the NF-kappaB, AP-1 and STAT signaling pathways
Corsten et al., Cancer Res 2007 (Brain Neoplasms...) : With the use of locked nucleic acid ( LNA ) -antimiR-21 oligonucleotides, bimodal imaging vectors, and neural precursor cells (NPC) expressing a secretable variant of the cytotoxic agent tumor necrosis factor related apoptosis inducing ligand ( S-TRAIL ), we show that the combined suppression of miR-21 and NPC-S-TRAIL leads to a synergistic increase in caspase activity and significantly decreased cell viability in human glioma cells in vitro
Lee et al., Biomed Pharmacother 2007 (Carcinoma...) : To delineate the oncogenic role of LMP1 in NPC , we first investigated the induction of MMP1, MMP2, MMP3 and MMP9 in LMP1 positive NPC tumor samples ( n=15 ) by quantitative RT-PCR
Broering et al., J Hepatol 2008 : Murine HCV replicon bearing MH1 cells were incubated with supernatants from TLR1-9 stimulated murine NPC ( Kupffer cells ( KC ), liver sinusoidal endothelial cells ( LSEC ) ) and bone marrow derived myeloid dendritic cells (mDC) ... TLR3- and TLR4 stimulated NPC are able to regulate HCV replication through production of IFN-beta
Vadalà et al., Spine (Phila Pa 1976) 2008 : Recent evidences showed that intradiscal injection of MSC effectively alter the course of IDD in vivo, and the regenerative potential may result from up-regulated extracellular matrix protein synthesis mediated by MSC and NPC interaction ... Two weeks of coculture cell interaction in a 3-dimensional environment induces a change in MSCs towards a more chondrogenic gene expression profile indicating MSC differentiation, and NPC gene expression changes in matrix and chondrogenic genes demonstrating only a modest trophic effect of MSC on NPC
Bator et al., Mediators Inflamm 1993 : NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs ... NPC 15669 caused significant inhibition of CPB associated increase in CD18 upregulation, lung tissue myeloperoxidase content, and percentage wet weight compared to controls
Xu et al., Biochemistry 2008 (Niemann-Pick Disease, Type C) : Niemann-Pick disease type C (NPC) is caused by defects in either the NPC1 or NPC2 gene and is characterized by accumulation of cholesterol and glycolipids in the late endosome/lysosome compartment
Qi et al., ORL J Otorhinolaryngol Relat Spec 2009 (Disease Progression...) : This study is designed to investigate the roles of Tiam1 and Rac1 in nasopharyngeal carcinoma (NPC) ... This study is designed to investigate the roles of Tiam1 and Rac1 in nasopharyngeal carcinoma (NPC)
Hwang et al., Am J Pathol 2009 (Disease Progression...) : These findings suggest that NOLC1 plays a role in the regulation of tumorigenesis of NPC and demonstrate that both NOLC1 and tumor protein 53 work together synergistically to activate the MDM2 promoter in NPC cells
Hoe et al., Pathology 2009 (Adenocarcinoma...) : To determine the role of p53 in NPC , we screened for p53 mutations and evaluated the protein expression levels in samples from local patients with NPC
Ajmone-Cat et al., J Neurochem 2010 (Encephalitis...) : We thus investigated whether IL-1alpha could contribute to the effects of acutely activated microglia on NPC
Tong et al., BMC cancer 2010 (Carcinoma...) : The functional role of DAB2 in NPC was investigated by re-introducing DAB2 expression into NPC cell line C666-1
Rosenbaum et al., J Med Chem 2010 (Niemann-Pick Diseases) : Lysosomal acid lipase (LAL) has been recently identified as a potential therapeutic target for NPC
Xie et al., Journal of oncology 2010 : These data indicate that ABCC2 may play an important role in NPC resistant to CDDP
Aguirre et al., Nature 2010 : In the SVZ, Notch regulates NSC identity and self-renewal, whereas EGFR specifically affects NPC proliferation and migration
Zeng et al., Journal of proteomics 2011 (Nasopharyngeal Neoplasms) : Our results suggest that the differential radioresponsive proteins unique to CNE2p/SUPER may be involved in p53 mediated radioresponse in NPC, which will be helpful for elucidating the mechanisms of p53 mediated NPC cellular response to radiotherapy
Horikawa et al., Br J Cancer 2011 (Nasopharyngeal Neoplasms...) : We have recently investigated the involvement of epithelial-mesenchymal transition (EMT) in NPC
Maeshima et al., Nucleus (Austin, Tex.) 2011 (Neoplasms) : Recently, we demonstrated that cyclin dependent protein kinases (Cdks) control interphase NPC formation in dividing human cells
Huang et al., Oncogene 2012 (Carcinoma...) : Activation of CRYAB suppressed NPC tumor formation in nude mice ... Overexpression of CRYAB affected NPC progression associated phenotypes such as loss of cell adhesion, invasion, interaction with the tumor microenvironment, invasive protrusion formation in three dimensional Matrigel culture, as well as expression of epithelial-mesenchymal transition associated markers
Ocuin et al., J Hepatol 2012 (MAP Kinase Signaling System...) : Nilotinib reduced NPC activation of p38 MAPK signaling and decreased the recruitment of inflammatory monocytes and their production of TNF ... Nilotinib reduced NPC activation of p38 MAPK signaling and decreased the recruitment of inflammatory monocytes and their production of TNF
Moon et al., Int J Nanomedicine 2012 (Brain Ischemia...) : The HP CNT-SVZ NPC and HL CNT-SVZ NPC transplants increased the number of microtubule associated protein 2 ( marker for neurons ) and decreased the number of glial fibrillary acidic protein ( marker for astroglial cells ) positive cells within the injury epicenter
Fineberg et al., PloS one 2012 : In this study we examined the role of miR-34a in neural progenitor cells (NPC) derived from murine embryonic cortex
Fang et al., Nan Fang Yi Ke Da Xue Xue Bao 2012 (Lymphatic Metastasis...) : Real-time PCR and immunohistochemistry were used to validate the detection results of CASP8 expression in NPC , and the correlation of CASP8 expression to the clinical characteristics was analyzed in the NPC cases
Jie et al., Asian Pac J Trop Med 2012 (Nasopharyngeal Neoplasms) : These findings suggest that Pim-1 overexpression contributes to NPC proliferation and migration, and targeting Pim-1 may be a potential treatment for anti-Pim-1 expressed NPCs
Pan et al., Cancer Lett 2012 (Disease Progression...) : In this review, we highlight recent advances in studies of the oncogenic role of Jab1/CSN5 in NPC and its potential as a therapeutic target for this cancer ... In this review, we highlight recent advances in studies of the oncogenic role of Jab1/CSN5 in NPC and its potential as a therapeutic target for this cancer
Rodríguez-Martínez et al., PloS one 2012 : After stimulation of NPC with Activin A , phosphorylation and nuclear translocation of Smad 2/3 were induced
Chou et al., Am J Pathol 2012 (Epstein-Barr Virus Infections...) : Therefore, the role of RON in EBV associated NPC and its metastasis was investigated ... These results suggest an important role of RON in the tumorigenesis and metastasis of NPC and RON may be a novel therapeutic target for EBV associated NPC
Luo et al., Carcinogenesis 2013 (Disease Progression...) : Collectively, our findings indicate that miR-18a plays an oncogenic role in the development of NPC by widespread downregulation of the miRNome and could be a potential therapeutic target for NPC
Kao et al., Tumour Biol 2013 (Nasopharyngeal Neoplasms) : However, the role of FASN in nasopharyngeal carcinoma (NPC) has not been studied
Shen et al., BMC cancer 2013 : However, the role of UBE2C in human nasopharyngeal carcinoma (NPC) is unclear
OuYang et al., Ann Oncol 2013 : NACT can effectively enhance OS and reduce DMR, not LRR in NPC
Pan et al., BMC cancer 2013 (Nasopharyngeal Neoplasms) : Therefore, it is important to seek for innovative therapeutics targeting Jab1/CSN5 for NPC ... Therefore, it is important to seek for innovative therapeutics targeting Jab1/CSN5 for NPC
Farmer et al., Mol Pharmacol 1989 : The inability of the antagonists to inhibit Bk is unlikely to be due to their degradation, because NPC567 was only weakly active in the presence of inhibitors of kininase I ( EC 3.4.11.2 ), kininase II ( EC 3.4.15.1 ), and neutral endopeptidase ( EC 3.4.24.11 ) ... The inability of the antagonists to inhibit Bk is unlikely to be due to their degradation, because NPC567 was only weakly active in the presence of inhibitors of kininase I ( EC 3.4.11.2 ), kininase II ( EC 3.4.15.1 ), and neutral endopeptidase ( EC 3.4.24.11 ) ... The inability of the antagonists to inhibit Bk is unlikely to be due to their degradation, because NPC567 was only weakly active in the presence of inhibitors of kininase I ( EC 3.4.11.2 ), kininase II ( EC 3.4.15.1 ), and neutral endopeptidase ( EC 3.4.24.11 )
Keller et al., Ann Surg 1985 : Although reagent H2O2 will inhibit protein synthesis when added to hepatocyte culture, LPS stimulated NPC do not release H2O2 and do not show chemiluminescence -- an in vitro correlate of the respiratory burst
Jorens et al., Eur Respir J 1994 : Intratracheal NPC 15669 prevented both IL-8- and Pseudomonas induced accumulation of neutrophils
Higashitsuji et al., J Surg Res 1995 : Both IL-1 alpha and beta mRNA increased transiently 1/2 to 1 hr after PH in nonparenchymal cells (NPC) of the regenerating liver ; they reached a maximum before the peak of hepatocyte DNA synthesis
Lu et al., J Exp Med 1994 : Further evidence that the GM-CSF stimulated class IIdim or class II-depleted hepatic NPC were immature DC was obtained by injecting them into allogeneic B10 ( H-2b I-E- ) recipients
Burch et al., J Immunol 1993 : These observations, coupled with the finding that NPC 15669 does not inhibit endotoxin induced TNF release suggest that inhibition of leukocyte sequestration can increase survival after endotoxin challenge, and that NPC 15669 or antibodies to Mac-1 may represent effective therapies for gram negative sepsis and shock
Sha et al., Invest New Drugs 1996 (Breast Neoplasms) : Experiments designed to investigate the mechanism by which NPC 15437 exerts these effects revealed that treatment with the protein kinase C activator phorbol-12-myristate 12-acetate partially reversed the effect of NPC 15437, suggesting that NPC 15437 was exerting an effect through protein kinase C. Photoaffinity labeling experiments revealed that NPC 15437 also inhibited the binding of [ 3H ] -azidopine to Pgp in isolated membrane vesicles
Mikulec et al., J Biomed Mater Res 1996 : An activity of 10.5 BAEE units was measured on both adsorbed and p-NPC activated Ti-6Al-4V , with the exception of samples derivatized with 1.95 mg p-NPC/cm2, on which activity was significantly lower ( 4 BAEE units )
Pudupakkam et al., Am J Physiol 1998 (Ischemia) : L-NAME and AMG prevented ischemia-reperfusion induced reduction in Npc in muscles without PC
Haaz et al., Drug Metab Dispos 1998 : The transformation of irinotecan into NPC was found to be catalyzed principally by cytochrome P450 (CYP) 3A, based on three key results, as follows : 1 ) the CYP3A-selective inhibitors ketoconazole ( 1 microM ) and troleandomycin ( 100 microM ) inhibited NPC formation by 99 and 100 %, respectively ; 2 ) of a series of microsomal preparations from transfected lymphoblastoid cells expressing specific CYPs, only those from CYP3A4 cDNA transfected cells transformed irinotecan into NPC ; and 3 ) incubations with 15 individual preparations of human liver microsomes yielded highly significant correlations between the formation of NPC and both immunoreactivity with anti-CYP3A antibodies and testosterone 6beta-hydroxylation ( an activity specifically mediated by CYP3A )