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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to NTRK1
NTRK1 — SOS1
Pathways - manually collected, often from reviews:
BioCarta role of erk5 in neuronal survival pathway :
neurotrophin/TRkA complex (NTF3_BDNF_NGFB-NTRK1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
BioCarta trka receptor signaling pathway :
NGF/TRkA complex (NTRK1-NGFB)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling :
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, activates)
Qian et al., Neuron 1998
mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling :
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
SH2B family/GRB2/SOS1 complex (GRB2-SOS1)
(modification, activates)
Qian et al., Neuron 1998
mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling :
SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1)
→
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
(modification, collaborate)
Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
mutant phenotype, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling :
GRB2/SOS1 complex (GRB2-SOS1)
→
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
(modification, collaborate)
Dixon et al., Biochim Biophys Acta 2006 , Kouhara et al., Cell 1997
mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling :
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2)
(modification, activates)
Dixon et al., Biochim Biophys Acta 2006 , Kouhara et al., Cell 1997
mutant phenotype, physical interaction, other species