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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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NFYC — PNRC2

Text-mined interactions from Literome

Zhou et al., Gene 2005 : Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1 ... Transient transfections and luciferase assays further revealed that overexpression of NFY enhanced-promoter activity of PNRC2 gene in a dose dependent manner while overexpression of E2F1 strongly repressed the activity of the PNRC2 promoter ... Since most genes regulated by E2F1 or NFY play a regulatory role in the cell cycle, the finding that the PNRC2 promoter is activated by NFY and repressed by E2F1 indicates that in addition to functioning as nuclear receptor coactivator, PNRC2 may also play a role in the cell cycle
Zhang et al., J Biochem 2008 : Transcriptional regulation of the human PNRC promoter by NFY in HepG2 cells ... Transient transfection and luciferase assays further revealed that over-expression of NFY represses promoter activity of PNRC gene in a dose dependent manner ... These results indicate that the transcription factor NFY specifically binds to promoter region of PNRC and negatively regulates the transcription of the human PNRC gene