◀ Back to NFYC
NFYA — NFYC
Pathways - manually collected, often from reviews:
-
BioCarta overview of telomerase rna component gene hterc transcriptional regulation:
RB (RB1)
→
NF-Y complex (NFYA-NFYB-NFYC)
(modification, activates)
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
NF-Y complex (NFYA-NFYB-NFYC)
(modification, collaborate)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
NF-Y complex (NFYA-NFYB-NFYC)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
PDGFRB (PDGFRB)
(transcription, inhibits)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
NF-Y complex (NFYA-NFYB-NFYC)
(transcription, inhibits)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer)/NF-Y complex (TP53-NFYA-NFYC-NFYB)
→
NF-Y complex (NFYA-NFYB-NFYC)
(modification, collaborate)
Imbriano et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer)/NF-Y complex (TP53-NFYA-NFYC-NFYB)
→
p53 (tetramer) complex (TP53)
(modification, collaborate)
Imbriano et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Direct p53 effectors:
NF-Y complex (NFYA-NFYB-NFYC)
→
p53 (tetramer) complex (TP53)
(modification, collaborate)
Imbriano et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
NFYA
→
NFYC
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
NFYA
—
NFYC
(physical association, affinity chromatography technology)
Yun et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
NFYA
—
NFYC
(direct interaction, two hybrid)
Bandyopadhyay et al., Nat Methods 2010
-
MIPS CORUM CBF-DNA complex:
CBF-DNA complex complex (NFYA-NFYB-NFYC)
Chattopadhyay et al., Nucleic Acids Res 2004*
-
MIPS CORUM p32-CBF-DNA complex:
p32-CBF-DNA complex complex (C1QBP-NFYA-NFYB-NFYC)
Chattopadhyay et al., Nucleic Acids Res 2004*
-
IRef Corum Interaction:
Complex of NFYB-NFYA-C1QBP-NFYC
(association, pull down)
Chattopadhyay et al., Nucleic Acids Res 2004*
-
IRef Hprd Interaction:
NFYA
—
NFYC
(in vitro)
Chattopadhyay et al., Nucleic Acids Res 2004*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Currie et al., J Biol Chem 1998*
-
IRef Intact Interaction:
Complex of 13 proteins
(physical association, x-ray crystallography)
Nardini et al., Cell 2013*
-
IRef Intact Interaction:
NFYA
—
NFYC
(physical association, two hybrid pooling approach)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Intact Interaction:
Complex of SRSF1-NFYC-NFYA-NFYB-SRSF1-NFYC-NFYA-NFYB
(association, coimmunoprecipitation)
Chattopadhyay et al., Nucleic Acids Res 2004*
-
IRef Ophid Interaction:
NFYA
—
NFYC
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Dooley et al., J Biol Chem 1999
:
We have previously shown that, in addition to SREBPs,
NF-Y/CBF is
required for sterol regulated transcription of
HMG-CoA synthase
Kreuter et al., J Lipid Res 1999
:
Overexpression of a dominant negative NF-YA vector confirmed
involvement of
NF-Y in the regulation of the
VLDL-receptor gene through the CCAAT box
Takizawa et al., Nihon Hoigaku Zasshi 1998
:
5. Transcription of the human blood group
ABO gene can be
enhanced by a
CBF/NF-Y which binds the minisatellite on the 5'-upstream sequence of the gene
Farina et al., Oncogene 1999
:
Addition of recombinant NF-YA to TD C2C12 nuclear extracts restores binding activity in vitro, thus indicating that the loss of
NF-YA in TD cells is
responsible for the lack of the
NF-Y binding to the CCAAT boxes ... In conclusion, our data demonstrate that
NF-Y is
required for
cyclin B1 promoter activity
Huang et al., FEBS Lett 1999
(Carcinoma, Squamous Cell) :
The CCAAT-box binding factor
NF-Y is
required for the expression of phospholipid hydroperoxide
glutathione peroxidase in human epidermoid carcinoma A431 cells
Kamiyama et al., FEBS Lett 1999
:
The ubiquitous transcription factor
NF-Y positively
regulates the transcription of human
p27Kip1 through a CCAAT box located in the 5-upstream region of the p27Kip1 gene ... Gel shift assays and cotransfection experiments using a dominant negative form of the NF-Y transcription factor showed that
NF-Y directly
regulates p27Kip1 transcription through this CCAAT box
Wang et al., Mol Endocrinol 1999
(Breast Neoplasms) :
Transcriptional activation of
E2F1 gene expression by 17beta-estradiol in MCF-7 cells is
regulated by
NF-Y-Sp1/estrogen receptor interactions ... Thus, transcriptional activation of
E2F1 gene expression in MCF-7 cells by E2 is
regulated by multiprotein
ER/Sp1-NF-Y interactions at GC-rich and two CCAAT elements in the proximal region of the E2F1 gene promoter
Yun et al., J Biol Chem 1999
:
These results suggest that
p53 negatively regulates cdc2 transcription and that the
NF-Y transcription factor is
required for the p53 mediated regulation
Sorensen et al., J Biol Chem 1999
:
Sp1 and
NF-Y are
necessary and sufficient for growth dependent regulation of the hamster
thymidine kinase promoter
Hu et al., J Biol Chem 2000
:
Taken together, these results indicate a
role for both
NF-Y and Sp1 in the transcriptional activation of the
MDR1 gene by genotoxic stress, and indicate that YB-1, if involved, is not sufficient to mediate this activation
Yamada et al., J Biol Chem 2000
:
Thus, we conclude that Sp1, Sp3, and
NF-Y stimulate the transcription of the
PKM gene via their interactions
Li et al., Mol Cell Biol 2000
:
ATF6 as a transcription activator of the endoplasmic reticulum stress element : thapsigargin stress
induced changes and synergistic interactions with
NF-Y and YY1
Caretti et al., J Mol Biol 2000
:
When tested on a highly positioned nucleosome,
RFX binds DNA well and
NF-Y does not
increase its affinity further
Ubeda et al., Nucleic Acids Res 2000
:
CHOP gene expression in response to endoplasmic-reticular stress
requires NFY interaction with different domains of a conserved DNA binding element ... These findings support the notion that
NFY is not only
required for constitutive activation of
CHOP gene transcription, but is also an active and essential element for the assembly of an ER-stress-inducible enhanceosome that activates CHOP gene expression in response to cellular stress
Farsetti et al., Endocrinology 2001
:
In conclusion, our results demonstrate that heteromeric transcription factor
NF-Y inhibits estrogen induction of
coagulation factor XII promoter in a DNA binding independent fashion and suggest a novel role for NF-Y as a partner for the ERalpha transcription complex
Iwano et al., Biochem Biophys Res Commun 2001
:
Cooperative
regulation of
CYP3A5 gene transcription by
NF-Y and Sp family members ... Thus, we conclude that the transcription of the
CYP3A5 gene is cooperatively
regulated by
NF-Y , Sp1, and Sp3 in HepG2 cells
Wolf et al., Biol Chem 2001
:
The FIRE3 mediated sterol response of the
FAS promoter
requires NF-Y/CBF as a coactivator
Kauffmann et al., Toxicology 2001
(Carcinoma, Hepatocellular...) :
Basal expression of the rat, but not of the human,
multidrug resistance protein 2 (MRP2) gene is
mediated by
CBF/NF-Y and Sp1 promoter binding sites
Eggen et al., FEBS Lett 2001
:
Our results demonstrate that
JunB gene activation by TAK1 is
mediated by the CCAAT binding factor
NF-Y ... Our results demonstrate that JunB gene activation by
TAK1 is
mediated by the CCAAT binding factor
NF-Y
Frontini et al., J Biol Chem 2002
:
Using agarose-electrophoretic mobility shift assay we found that
NF-Y increases the affinity of
holo-TFIID for Ea in a CCAAT- and Inr dependent manner
Park et al., J Biol Chem 2002
(Breast Neoplasms) :
Transcriptional regulation of the
transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is
mediated by
NF-Y in human breast cancer cells
Curtis et al., Leukemia 2001
:
NF-Y regulates LIF induced transcription of the signaling adaptor
SKAP55R in myeloid cells
Nackley et al., Endocrinology 2002
:
YY1 inhibited SREBP-1a/nuclear factor Y (NF-Y) enhancement of StAR activation and YY1 decreased
SREBP-1a binding to a sterol regulatory element in the
presence or absence of
NF-Y ... YY1 inhibited SREBP-1a/nuclear factor Y (NF-Y) enhancement of StAR activation and
YY1 decreased SREBP-1a binding to a sterol regulatory element in the
presence or absence of
NF-Y
Côté et al., J Neurochem 2002
:
Involvement of
NF-Y and Sp1 in basal and cAMP stimulated transcriptional activation of the
tryptophan hydroxylase (TPH ) gene in the pineal gland
Sjin et al., Blood 2002
:
A dominant negative form of
NF-YA , ectopically expressed in M1 cells,
blocked NF-Y binding to the -65/-52 IL-6RE and reduced induction of JunB by IL-6 ... A dominant negative form of NF-YA, ectopically expressed in M1 cells, blocked
NF-Y binding to the -65/-52 IL-6RE and reduced
induction of
JunB by IL-6
Nagai et al., Biochem Biophys Res Commun 2002
:
SREBP-2 and
NF-Y are
involved in the transcriptional regulation of
squalene epoxidase
Molander et al., Mol Biol Rep 2001
:
Furthermore, transfection of NF-Y failed to enhance transcriptional activity when the Sp1 binding sites were deleted from the promoter, suggesting an important
role for
Sp1 in this
NF-Y controlled transcription
Lok et al., Biochem J 2002
:
Co-transfection experiments using a dominant negative form of subunit A of NF-Y suggested that
TOP2B promoter activity
required direct interaction of
NF-Y with the ICBs ... Our results suggest that the binding sites for
NF-Y and Sp1 are
critical for
TOP2B transcription
Matuoka et al., Ageing Res Rev 2002
:
In fact, the activities of
NF-Y and E2F decrease during ageing and a dominant negative
NF-YA induces SA-gal
Bernardin et al., Cancer Biol Ther 2002
(Leukemia, Myeloid) :
CBFbeta-SMMHC is expressed from the inv ( 16 ) chromosome in 8 % of AML cases and
inhibits endogenous
CBF DNA binding ...
CBFbeta-SMMHC is expressed from the inv ( 16 ) chromosome in 8 % of AML cases and
inhibits endogenous
CBF DNA binding
Nicolás et al., Biochem J 2003
:
Whereas overexpression of
NF-Y or E2F
had an additive effect on
Sp1 overexpression, the activation of Sp1 transcription due to Sp1 was counteracted by Sp3 overexpression
Joshi et al., Mol Pharmacol 2003
:
The expression of mutant
p53 does not
affect the binding of
NF-Y
Luo et al., Biochem Biophys Res Commun 2003
:
The regulation of
catalase gene expression in mouse muscle cells is
dependent on the CCAAT binding factor
NF-Y
Bernadt et al., Mol Reprod Dev 2003
(Carcinoma, Embryonal) :
We demonstrate that the CCAAT box and two flanking GC boxes, Sp A and Sp B, function as positive regulatory elements in the human TbetaR-II promoter, and that the transcription factor complex
NF-Y positively
regulates the human
TbetaR-II promoter through the CCAAT box motif
Clem et al., Gene 2003
:
Characterization of the
role of Sp1 and
NF-Y in differential regulation of
PTTG/securin expression in tumor cells
Fang et al., J Biol Chem 2004
:
We also show that the efficiency of gamma gene transcription is correlated with recruitment of TBP on the TATA box but that the level of
TBP recruitment is not
nuclear factor Y (NF-Y) dependent
Matsui et al., J Biol Chem 2004
:
Negative regulation of
Chk2 expression by p53 is
dependent on the CCAAT binding transcription factor
NF-Y
Zhu et al., J Biol Chem 2004
:
Electrophoretic mobility shift assays, however, revealed that nuclear factor Y (NF-Y), but not C/EBPalpha, directly bound to this site although increased expression of
NF-Y had no effect on
EPHX1 promoter activity
Huang et al., Nucleic Acids Res 2004
:
GATA-1 and
NF-Y cooperate to
mediate erythroid-specific transcription of
Gfi-1B gene
Poch et al., Toxicol Appl Pharmacol 2004
:
Attempts to demonstrate a
role for
NF-Y/ACTN4 in regulating
CYP1A1 expression were unsuccessful, likely due to an inability to significantly change nuclear ACTN4 levels with phosphatidylinositol 3'-kinase agonists and antagonists
Pandey et al., J Biol Chem 2004
:
Parallel to the loss of antisense transcription, the loss of silencing of the flanking reporter genes was observed, suggesting that
NF-Y mediated
Kcnq1ot1 transcription is critical in the bidirectional silencing process of the Kcnq1 ICR
Kadariya et al., Biochem J 2005
:
Regulation of human
methylthioadenosine phosphorylase gene by the CBF ( CCAAT binding factor )
/NF-Y ( nuclear factor-Y )
Yamamoto et al., J Biochem 2004
:
In this report, we show that ERSE-II allows the
NF-Y dependent binding of
ATF6 as in the case of ERSE and NF-Y independent binding of XBP1 as in the case of UPRE, and that transcription from ERSE-II is mitigated in the absence of XBP1
Kabe et al., Mol Cell Biol 2005
:
ODF gene induction by parathyroid hormone or prostaglandin E is also
dependent on
NF-Y
Zhao et al., BMC cancer 2005
:
Mdm2 may directly
repress activation by both pRB and Sp1, or activation by
NF-Y ... Mdm2 may directly repress activation by both pRB and
Sp1 , or
activation by
NF-Y ... Mdm2 may directly repress activation by both
pRB and Sp1, or
activation by
NF-Y
Lee et al., J Cell Physiol 2005
:
Furthermore, EMSA data revealed that expression of
myr-Akt promoted the binding of
NF-Y to the consensus CCAAT promoter sequence, whereas expression of km-Akt almost completely abolished it
Bernadt et al., Gene Expr 2005
(Carcinoma, Embryonal) :
Previous studies have shown that the
FGF-4 promoter is
regulated positively by its CCAAT box and
NF-Y in embryonal carcinoma ( EC ) cells where the distal enhancer of the FGF-4 gene is active
Zhou et al., Gene 2005
:
Transcriptional
regulation of the mouse
PNRC2 promoter by the
nuclear factor Y (NFY) and E2F1 ... Transient transfections and luciferase assays further revealed that overexpression of
NFY enhanced-promoter activity of PNRC2 gene in a dose dependent manner while overexpression of E2F1 strongly
repressed the activity of the
PNRC2 promoter ... Since most genes regulated by E2F1 or NFY play a regulatory role in the cell cycle, the finding that the
PNRC2 promoter is
activated by
NFY and repressed by E2F1 indicates that in addition to functioning as nuclear receptor coactivator, PNRC2 may also play a role in the cell cycle
Bolognese et al., Gene 2006
:
Our studies indicate that Sp1 and
NFY binding is
essential for
EDF-1 promoter activity
Dong et al., Biochem J 2006
:
NF-Y and Sp1/Sp3 are
involved in the transcriptional regulation of the
peptidylarginine deiminase type III gene ( PADI3 ) in human keratinocytes
Leclerc et al., BMC cancer 2006
(Leukemia, Lymphoid...) :
Finally, we determined that the putative transcription factor binding site
NFY , but not E-box,
plays a role in
FPGS transcription in both Bp- and T-lineage
Mahishi et al., Biochem J 2006
:
NF-Y , AP2, Nrf1 and Sp1
regulate the
fragile X-related gene 2 (FXR2)
Park et al., Clin Cancer Res 2007
(Colorectal Neoplasms...) :
NF-Y dependent
cyclin B2 expression in colorectal adenocarcinoma ... The transcriptional
regulation of
cyclin B2 by
NF-Y was analyzed using an in vitro transfection assay and an in vivo chromatin immunoprecipitation assay
Rodríguez et al., Ann N Y Acad Sci 2006
:
The absence of TATA box and the location and reverse orientation of the CCAAT boxes in the promoter region strongly suggest a
role for
NF-Y in the regulation of transcription of SND
p102 gene
Boily et al., Biochim Biophys Acta 2007
(Neuroblastoma) :
These studies performed on chromatin in situ suggest that
NFY and yet unknown cell type-specific factors may
play an important role in the regulation of
GPC3
Rodríguez et al., Biochem Biophys Res Commun 2007
:
NF-Y and Sp1 are
involved in transcriptional regulation of rat SND
p102 gene
Peng et al., Oncogene 2007
:
We have also demonstrated that irradiation
increases the association of
NF-Y with histone acetyltransferase
p300/CBP associated factor (PCAF) ... We demonstrate that irradiation induced changes in association of
NF-Y with HDAC1 and PCAF
lead to increased
PCAF recruitment to the VWF promoter, increased association of acetylated histone H4 with the VWF promoter and subsequently increased transcription
Zhu et al., Biochim Biophys Acta 2007
:
The CCAAT binding factor
CBF/NF-Y regulates the human
acetylcholinesterase promoter activity during calcium ionophore A23187 induced cell apoptosis ... In the present study, we investigated the molecular mechanisms by which
CBF/NF-Y regulates A23187 induced activation of the human
acetylcholinesterase promoter
Krstic et al., Arch Biochem Biophys 2007
(Carcinoma) :
The
involvement of
NF-Y in the up-regulation of
SOX3 expression in NT2/D1 cells was demonstrated in vivo by Northern and Western blot analyses ... Furthermore, in co-transfection experiments we have shown that
NF-Y mediates transcriptional activation of
SOX3 promoter
Tomita et al., BMC molecular biology 2008
:
Regulation of mouse
Scgb3a1 gene expression by
NF-Y and association of CpG methylation with its tissue-specific expression ... By reporter gene transfection and gel mobility shift analyses, we demonstrated that expression of the mouse
Scgb3a1 gene is
regulated by a PU-box binding protein and a ubiquitous transcription factor
NF-Y that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp, and the `` CCAAT '' binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene ... A ubiquitous transcription factor
NF-Y binds to and
activates expression of the mouse
Scgb3a1 gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter
Shareef et al., Mol Cancer Res 2008
(Mouth Neoplasms) :
Lack of
P-glycoprotein expression by low-dose fractionated radiation
results from loss of nuclear factor-kappaB and
NF-Y activation in oral carcinoma cells
Zhang et al., J Biochem 2008
:
Transcriptional
regulation of the human
PNRC promoter by
NFY in HepG2 cells ... Transient transfection and luciferase assays further revealed that over-expression of
NFY represses promoter activity of
PNRC gene in a dose dependent manner ... These results indicate that the transcription factor
NFY specifically binds to promoter region of PNRC and negatively
regulates the transcription of the human
PNRC gene
Jun et al., Gene 2008
:
Positive regulation of promoter activity of human
3-phosphoglycerate dehydrogenase (PHGDH) gene is
mediated by transcription factors Sp1 and
NF-Y
Chen et al., J Biol Chem 2008
:
BMP2 induces
NF-Y accumulation into the nucleus increasing its recruitment to the mouse DSPP promoter in vivo ... Furthermore, forced overexpression of
NF-Y enhances promoter activity and
increases endogenous
DSPP protein levels
Mauvoisin et al., Journal of cell communication and signaling 2007
:
The latter binds both
NF-Y and SREBP-1 transcription factors in
response to
insulin ... The most 3 ' IRE is localized between -372 and -297 bp and binds the
NF-Y and SREBP-1 transcription factors in
response to
insulin
Kotecha et al., Mol Cancer Ther 2008
:
In this study, we investigated the ability of
GWL-78 , a pyrrolobenzodiazepine-poly ( N-methylpyrrole ) conjugate, to
inhibit the binding of
NF-Y to DNA
Petrovic et al., Mol Biol Rep 2009
:
In this paper, for the first time, we have demonstrated that Sp3, ZBP-89 and
NF-Y are
involved in transcriptional regulation of the human
SOX18 gene expression
Lecona et al., Mol Cell Biol 2008
(Adenocarcinoma...) :
Upregulation of
annexin A1 expression by butyrate in human colon adenocarcinoma cells : role of p53,
NF-Y , and p38 mitogen activated protein kinase
Damiano et al., Biochem J 2009
:
Our data show that PUFA inhibition of hepatic Cic gene transcription is mediated not only by the nuclear level of
SREBP-1c , but also might
involve a reduction in Sp1 and
NF-Y DNA binding, suggesting differential mechanisms in the Cic gene regulation by different PUFA ... Our data show that PUFA inhibition of hepatic
Cic gene transcription is mediated not only by the nuclear level of SREBP-1c, but also might
involve a reduction in Sp1 and
NF-Y DNA binding, suggesting differential mechanisms in the Cic gene regulation by different PUFA
Pan et al., Biochem Biophys Res Commun 2009
:
Immunoprecipitation ( IP ) experiments demonstrated that
BMP-2 increased the association of the transcription factor
NF-Y with histone acetyltransferase p300/CBP ... Immunoprecipitation ( IP ) experiments demonstrated that BMP-2
increased the association of the transcription factor
NF-Y with histone acetyltransferase
p300/CBP
Yun et al., Cancer research and treatment : official journal of Korean Cancer Association 2006
:
p53 is essential to prevent immature escaping from cell cycle G2 checkpoint arrest through p21 mediated cdk2 inactivation, and this
leads to inhibition of cdk2 dependent
NF-Y phosphorylation and NF-Y dependent transcription of the cell cycle G2-regulatory genes, including cdc2 and cyclin B
Pallai et al., Gene 2010
(Liver Neoplasms...) :
The CCAAT box binding transcription factor,
nuclear factor-Y (NF-Y) regulates transcription of human
aldo-keto reductase 1C1 (AKR1C1) gene ... Site directed mutagenesis studies indicated that the transcription factor binding sites for
NF-Y/CEBP were
involved in controlling the basal transcription of
AKR1C1 in all the cancer cells studied ... These results indicate that the
NF-Y regulates the basal transcription of
AKR1C1 in human ovarian, lung and liver carcinoma cells and the cisplatin induced transcription in human ovarian carcinoma cells
Wu et al., Acta Med Okayama 2010
:
Therefore, the transcription of the mouse
Col5a3 gene is cooperatively
regulated by Sp1 and
CBF/NF-Y in osteoblastic cells
Ishimoto et al., Biochem J 2010
(Hepatoblastoma...) :
We show that the SREBP-2- and
NF-Y mediated regulation of
FDPS gene transcription modulates cell proliferation
Gurtner et al., Cancer Res 2010
:
Transcription factor
NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and
p53 activation ... Transcription factor
NF-Y induces apoptosis in cells expressing wild-type p53 through
E2F1 upregulation and p53 activation
Tue et al., Gene 2011
:
NF-Y transcriptionally
regulates the Drosophila
p53 gene
Hou et al., International journal of biological sciences 2010
:
Nuclear factor-Y (NF-Y) regulates transcription of mouse
Dmrt7 gene by binding to tandem CCAAT boxes in its proximal promoter ... This suggests that
NF-Y can
activate the
Dmrt7 promoter
Park et al., Cardiovasc Res 2011
:
Anthracycline down-regulation of GATA4 is mediated by the inhibition of Gata4 gene transcription via a novel mechanism that involves the
p53 dependent inhibition of
CBF/NF-Y binding to the CCAAT box within the Gata4 promoter
Hughes et al., Cell Death Differ 2011
:
We demonstrate that
NF-Y activity is essential for endogenous Bim expression and
contributes to
NGF withdrawal induced death
Chae et al., BMB Rep 2011
:
Our findings are additionally indicative of a role for Cyclin A in activating Cyclin B/CDK1 through promoting
NF-Y dependent transcription of Cyclin B and
CDC2 ; NF-Y mediated crosstalk may therefore help to orchestrate cell-cycle progression
Heibel et al., PloS one 2012
:
The presented data strongly suggest that Sp1, CREB, HNF-1, and
NF-Y , that are known to be responsive to hormones and diet,
regulate NAGS transcription
Lützner et al., PloS one 2012
:
Gene expression of the tumour suppressor
LKB1 is
mediated by Sp1,
NF-Y and FOXO transcription factors ... Taken together, these results demonstrate that Sp1,
NF-Y and FOXO transcription factors are
involved in the regulation of
LKB1 transcription
Oleaga et al., Mol Nutr Food Res 2013
:
Cocoa flavanol metabolites activate HNF-3ß, Sp1, and
NFY mediated transcription of
apolipoprotein AI in human cells ... Incubation with 3-methyl-epicatechin led to an increase in HNF-3ß mRNA, HNF-3ß, ER-a,
Sp1 , and NFY protein levels and the activation of ApoAI transcription
mediated by
NFY , Sp1, and ER-a ... Incubation with 3-methyl-epicatechin led to an increase in HNF-3ß mRNA, HNF-3ß, ER-a, Sp1, and NFY protein levels and the activation of
ApoAI transcription
mediated by
NFY , Sp1, and ER-a
Silvestre-Roig et al., Arterioscler Thromb Vasc Biol 2013
(Atherosclerosis...) :
Nuclear factor-Y (NF-Y) plays a major role in transcriptional activation of the
CYCLIN B1 gene (CCNB1) , a key positive regulator of cell proliferation and neointimal thickening
Nabokina et al., Gene 2013
:
The
requirement for
NF-Y in
SLC25A19 promoter activity in vivo was directly confirmed by the use of a dominant negative NF-YA mutant in transiently transfected HepG2 cells
Huang et al., Neoplasia (New York, N.Y.) 2013
:
Using a wide array of molecular, genetic, and functional approaches, we demonstrate that
PTEN enhances a transcriptional complex containing gain-of-function mutant p53, CBP, and
NFY in human glioblastoma cells and tumor tissues
Li et al., Hepatitis monthly 2013
:
Site directed mutagenesis studies suggested that
nuclear factor-Y (NF-Y) plays an important role in this HBx induced
AKR1C1 activation
Reed et al., Brain Res 1995
:
NF-Y activates mouse
tryptophan hydroxylase transcription
Li-Weber et al., J Immunol 1994
:
The
role of
NF-Y and IRF-2 in the regulation of human
IL-4 gene expression ... These findings suggest that
NF-Y may
play an important role in the regulation of
IL-4 gene expression
Szabo et al., Mol Cell Biol 1993
:
Identification of cis acting regulatory elements
controlling interleukin-4 gene expression in T cells : roles for
NF-Y and NF-ATc
Framson et al., J Biol Chem 1993
:
A serum response element and a binding site for
NF-Y mediate the serum response of the human
thrombospondin 1 gene
Hung et al., J Biol Chem 1996
:
Liver enriched transcription factor HNF-4 and ubiquitous factor
NF-Y are
critical for expression of blood
coagulation factor X
Jabrane-Ferrat et al., Mol Cell Biol 1996
(Burkitt Lymphoma) :
Second,
NF-Y , which binds to the Y box and increases interactions between RFX and the X box, also
increases the binding of
RFX to the S box ... We conclude that RFX binds to S and X boxes and that complex interactions between RFX and
NF-Y direct B-cell-specific and
interferon gamma-inducible expression or major histocompatibility complex class II genes
Ericsson et al., J Biol Chem 1996
:
We now demonstrate that the binding of recombinant
SREBP-1 to its cognate site ( SRE-3 ) within the FPP synthase promoter in vitro is
enhanced by binding of
NF-Y to the upstream inverted CCAAT box ... In contrast,
NF-Y does not
stimulate the binding of
SREBP-1 to SRE-3 when the inverted CCAAT box is either mutated or 4 base pairs ( bp ) are inserted between the inverted CCAAT box and SRE-3 ... These studies suggest that the binding of
SREBP-1 to SRE-3 in the FPP synthase promoter, and subsequent stimulation of transcription, is
dependent on synergistic binding and a functional interaction between SREBP-1 and
NF-Y ... These studies suggest that the binding of SREBP-1 to SRE-3 in the
FPP synthase promoter, and subsequent stimulation of transcription, is
dependent on synergistic binding and a functional interaction between SREBP-1 and
NF-Y
Good et al., Biol Signals 1996
:
Cell cycle- and age dependent transcriptional regulation of human thymidine kinase gene : the
role of
NF-Y in the
CBP/tk binding complex ... Cell cycle- and age dependent transcriptional regulation of human
thymidine kinase gene : the
role of
NF-Y in the CBP/tk binding complex
Pise-Masison et al., Mol Cell Biol 1997
:
We further demonstrate that
Tax1 specifically
activated the
NF-Y-responsive DQbeta promoter, as well as a minimal promoter which contains only the Y-box element
Ericsson et al., J Biol Chem 1997
:
These studies demonstrate that the regulated expression of the mitochondrial
GPAT gene
requires both
NF-Y and ADD1/SREBPs
Novak et al., Biochem Biophys Res Commun 1997
:
Cotransfection of HepG2 cells with both the -177 to -148 apoA-I CAT constructs and plasmid expressing NFY alpha and NFY beta, transactivated the apoA-I promoter by 1.8 fold, indicating that
NFY is a positive
activator of the
apoA-I gene
Katula et al., Cell Growth Differ 1997
:
These findings suggest that S phase-specific induction of the
cyclin B1 promoter is
dependent upon
NF-Y binding to the CCAAT elements and is correlated with activation by cyclin dependent kinases
Cao et al., Oncogene 1997
(Leukemia, Myelomonocytic, Acute...) :
CBF beta-SMMHC , expressed in M4Eo AML,
reduced CBF DNA binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells ... CBF
beta-SMMHC , expressed in M4Eo AML,
reduced CBF DNA binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells
Lamb et al., Mol Reprod Dev 1997
:
NF-Y binds to the CCAAT box motif of the FGF-4 gene and
promotes FGF-4 expression in embryonal carcinoma cells ... Hence, we provide strong evidence that the transcription factor
NF-Y is
involved in the expression of the
FGF-4 gene
Kominato et al., J Biol Chem 1997
:
Transcription of human
ABO histo-blood group genes is
dependent upon binding of transcription factor
CBF/NF-Y to minisatellite sequence ... Thus, transcriptional regulation of the human
ABO genes is
dependent upon binding of
CBF/NF-Y to the minisatellite
Takashima et al., J Biol Chem 1998
:
Deletion of the region from -60 to -40, which contains parts of both the Sp1 and NF-Y binding sites, completely abolished the promoter activity, suggesting that both Sp1 and
NF-Y are synergetically
involved in transcription regulation of the
mST8Sia IV/PST gene in P19 and F11 cells
Jackson et al., J Lipid Res 1998
:
Gel mobility shift assays demonstrated that the synergistic binding of
SREBP-1a to SRE-3 was
dependent on the binding of recombinant
nuclear factor Y (NF-Y) to the DNA, consistent with the in vivo regulation studies
Jin et al., Mol Cell Biol 1998
:
Transcriptional regulation of the
MDR1 gene by histone acetyltransferase and deacetylase is
mediated by
NF-Y
Teerawatanasuk et al., Brain Res Mol Brain Res 1998
(Mast-Cell Sarcoma) :
CBF/NF-Y activates transcription of the human
tryptophan hydroxylase gene through an inverted CCAAT box
Ueda et al., J Biol Chem 1998
:
We previously reported that the transcription of the human
macrophage stimulating protein (MSP) gene was positively
regulated by the binding of
NF-Y to the CAATT sequence in the promoter region of this gene
Yabuki et al., Eur J Biochem 1998
:
Involvement of
NF-Y in transcriptional regulation of the
phospholamban gene