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Li et al., J Biol Chem 2005
:
Finally, we found that TCR/CD28 costimulation induces IkappaBalpha, IkappaBbeta , and IkappaBepsilon degradation, and PKC is required for IkappaBalpha and IkappaBepsilon but not IkappaBbeta degradation
Harhaj et al., Mol Cell Biol 1996
:
Although IkappaBalpha degradation can be induced by phorbol ester alone, degradation of IkappaBbeta is largely dependent on the CD28 costimulatory signal