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AKT1 — NEUROD4

Text-mined interactions from Literome

Bang et al., J Cell Sci 2001 : Overexpression of Akt inhibits NGF induced growth arrest and neuronal differentiation of PC12 cells ... To investigate the role of Akt in nerve growth factor (NGF) induced neuronal differentiation , PC12 cells ectopically expressing wild-type or dominant-inhibitory forms of Akt were analyzed
Taraviras et al., Eur J Cell Biol 2002 (MAP Kinase Signaling System) : Epinephrine induced neuronal differentiation of PC12alpha2 cells through alpha2-AR activation in a subtype dependent manner, internalization of all human alpha2-AR subtypes, and activation of mitogen activated protein kinase ( MAPK ) and the serine-threonine protein kinase Akt
Oishi et al., Proc Natl Acad Sci U S A 2009 : Furthermore, active Akt increased the protein levels and transactivation activity of Mash1, a proneural basic helix-loop-helix protein required for the generation of neocortical GABAergic neurons, and Mash1 was required for Akt induced neuronal differentiation
Park et al., BMB Rep 2012 : However, the exact role of Akt in neuronal differentiation is still controversial
Noh et al., Mol Biol (Mosk) 2012 : Furthermore, NAC enhanced neuronal differentiation was mediated by activation of Akt
Cheng et al., PloS one 2013 : Taken together, these results provide in vivo evidence that Akt1 interacts with Notch signaling reciprocally and provide an explanation of why Akt1 is essential for the inhibition of neuronal differentiation
Zhang et al., Neural development 2013 : AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development ... These results show that N-cadherin regulates ß-catenin signaling through both Wnt and AKT, and suggest a previously unrecognized role for AKT in neuronal differentiation and cell survival during cortical development