Gene interactions and pathways from curated databases and text-mining

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HDAC3 — NCOR2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Guenther et al., Mol Cell Biol 2001 : In contrast, SMRT does not activate the class II HDAC4 , with which it also interacts
Guenther et al., Genes Dev 2002 : Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor SMRT for HDAC enzyme activity
Sohn et al., Mol Endocrinol 2003 : First, corepressor SMRT [ for silencing mediator of thyroid hormone receptor ( TR ) and retinoic acid receptor ( RAR ) ] inhibits the interaction of coactivator steroid receptor coactivator-1 with liganded TR/RAR
Dong et al., Oncogene 2003 : Studies comparing NuMA-RARalpha with NuMA-RARalpha ( deltaCC ) demonstrated that the dimerization or alpha-helical coiled-coil domain of NuMA was required for homodimer formation, transcriptional repression of wild-type RARalpha, transcriptional activation of STAT3 , and stability of the NuMA-RARalpha/SMRT complex
Takahashi et al., Blood 2004 (Leukemia) : In the presence of Flt3-ITD , PLZF-SMRT interaction was reduced, transcriptional repression by PLZF was inhibited, and PLZF mediated growth suppression of leukemia cells was partially blocked
Akaike et al., Mol Cell Biol 2004 : Furthermore, association of ERK5a and PPARgamma1 disrupted the interaction of SMRT and PPARgamma1, thereby inducing PPARgamma activation
Zhang et al., Genes Dev 2005 : Here we demonstrate that, in addition to protein-protein interactions with NCoR/SMRT , the activity of HDAC3 is regulated by both phosphorylation and dephosphorylation
Ki et al., Mol Cell Biol 2005 : The small interference RNA ( siRNA ) against SMRT abolished SMRT repression of the gene induction by C/EBPbeta or Nrf2
Hoberg et al., Mol Cell Biol 2006 : Introduction of nonphosphorylatable mutants of RelA/p65 and SMRT proteins or the inhibition of IKK activity results in active repression of NF-kappaB promoters by tethering the SMRT-HDAC3 complex
Lefebvre et al., Mol Endocrinol 2006 : Through direct phosphorylation of the corepressor silencing mediator for retinoic and thyroid hormone receptors ( SMRT ), Akt stabilized RAR/SMRT interaction, leading to an increased tethering of SMRT to the RARbeta2 promoter, decreased histone acetylation, down-regulation of the RARbeta2 expression, and impaired cellular differentiation in response to retinoid
Grégoire et al., Mol Cell Biol 2007 : Furthermore, the nuclear receptor corepressor SMRT ( silencing mediator of retinoid acid and thyroid hormone receptor ) stimulated the deacetylase activity of HDAC3 towards MEF2 and PCAF
Hoshino et al., J Biochem 2007 : Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression
Peterson et al., Mol Cell Biol 2007 (Breast Neoplasms) : SMRT is required for full expression of the ERalpha target genes cyclin D1, BCL-2 , and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ... SMRT is required for full expression of the ERalpha target genes cyclin D1 , BCL-2, and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ... SMRT is required for full expression of the ERalpha target genes cyclin D1, BCL-2, and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ... SMRT is required for full expression of the ERalpha target genes cyclin D1, BCL-2, and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ... SMRT is required for full expression of the ERalpha target genes cyclin D1, BCL-2, and progesterone receptor but not pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ... SMRT is required for full expression of the ERalpha target genes cyclin D1, BCL-2 , and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells
Higgins et al., Mol Endocrinol 2008 : This study illustrates that both SMRT and NCoR are involved in E2-dependent repression of VEGFR2 in MCF-7 cells
Stanya et al., J Cell Biol 2008 : Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT ... Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT ... Pin1 regulates SMRT protein stability, thereby affecting SMRT dependent transcriptional repression ... SMRT phosphorylation at multiple sites is required for Pin1 interaction, and these sites can be phosphorylated by Cdk2, which interacts with SMRT
Karmakar et al., Mol Endocrinol 2010 (Breast Neoplasms) : Our data link the SMRT corepressor directly with SRC family coactivators in positive regulation of ERalpha dependent gene expression and, taken with the positive correlation found for SMRT and SRC-3 in human breast tumors, suggest that SMRT can promote ERalpha- and SRC-3 dependent gene expression in breast cancer
Zhou et al., PloS one 2012 (MAP Kinase Signaling System) : Importantly, miR-16 targeted the 3'-untranslated region of SMRT and caused translational suppression of SMRT