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MUSK — RAPSN

Pathways - manually collected, often from reviews:

• BioCarta role of nicotinic acetylcholine receptors in the regulation of apoptosis: MUSK/RAPSYN/SRC/RAPSYN/SRC/ACH Receptor gamma polypeptide/ACH Receptor beta polypeptide 1/agrin complex (MUSK-RAPSN-SRC-CHRNG-CHRNB1-AGRN) → FAK (PTK2) (modification, activates)
• BioCarta role of nicotinic acetylcholine receptors in the regulation of apoptosis: MUSK/RAPSYN/SRC/RAPSYN/SRC/ACH Receptor gamma polypeptide/ACH Receptor beta polypeptide 1/agrin complex (MUSK-RAPSN-SRC-CHRNG-CHRNB1-AGRN) → PYK2 (PTK2B) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: MUSK — RAPSN (in vivo) Zhou et al., J Cell Biol 1999*, Apel et al., Neuron 1997*
• IRef Ophid Interaction: MUSK — RAPSN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lee et al., Neuroscience 2008 : Intriguingly, MuSK also induced tyrosine phosphorylation of rapsyn itself
Apel et al., Neuron 1997 : Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK containing scaffold