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FURIN — MMP9

Text-mined interactions from Literome

Stawowy et al., Cardiovasc Res 2004 : Furin , a subtilisin/kexin-like proprotein convertase ( PC ), activates TGF-beta1 and membrane bound MT1-MMP , which facilitates pro-gelatinase A ( MMP-2 ) activation
Wick et al., J Neurochem 2004 (Glioma...) : Both a pseudosubstrate furin inhibitor, decanoyl-Arg-Val-Lys-Arg-chloromethylketone ( dec-RVKR-cmk ), or alpha 1-anti-trypsin Portland ( PDX ), a recombinant furin-inhibitory protein, suppress constitutive and BCL-2 mediated MMP activity and invasion ... Consequently, HGF and BCL-2 family proteins use a furin dependent pathway to promote invasion via TGF-beta and MMP in human malignant glioma cells and the pro-invasive properties of TGF-beta require furin- dependent MMP activity
Shiryaev et al., PloS one 2009 (Multiple Sclerosis) : In sum, our biochemical observations led us to hypothesize that MT6-MMP , which is activated by furin and associated with the lipid rafts, plays an important role in MS pathology and that MT6-MMP is a novel and promising drug target in MS especially when compared with other individual MMPs
Zhou et al., Placenta 2009 : In contrast, over-expression of furin markedly increased cell invasion and migration ( P < 0.01 ), accompanied by significant increase of MMP-9 activities