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IGF1 — MMP13

Text-mined interactions from Literome

Hui et al., Ann Rheum Dis 2001 : IGF1 can also down regulate IL1alpha or IL1alpha + OSM induced MMP-1, MMP-3, MMP-8, and MMP-13 mRNA expression in human articular chondrocytes and bovine chondrocytes
Im et al., J Biol Chem 2003 : Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta stimulated matrix metalloproteinase-13 expression in human chondrocytes ... IGF-1 and OP-1 each significantly reduced the basal level as well as fibronectin fragment- or IL-1beta stimulated transcription of the MMP-13 gene in a dose dependent fashion with the corresponding decreases in the protein level of MMP-13 ... The suppressive effect of IGF-1 and OP-1 on MMP-13 expression was due in part to down-regulation of the expression of pro-inflammatory cytokines and the activity of their intermediate molecules, including NF-kappaB and AP-1 factors
Jenniskens et al., Osteoarthritis Cartilage 2006 : TGFbeta2 and IGF1 had no effect on MMP activity
Zhang et al., Osteoarthritis Cartilage 2009 (MAP Kinase Signaling System) : IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways ... The present study aimed to determine the role of IGF-1 on the mRNA expression of collagen type II, alpha 1 ( Col2a1 ) and matrix metallopeptidase 13 (MMP-13) in rat endplate chondrocytes ... Consistent with these results, IGF-1 also repressed MMP-13 activity ... The PI3K inhibitor Wartmannin significantly inhibited the IGF-1 effect on Col2a1 mRNA expression but did not affect IGF-1 induced repression of MMP-13 expression