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BAK1 — MCL1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: p53 (TP53) → BAK/MCL1 complex (BAK1-MCL1) (modification, collaborate)
  Leu et al., Nat Cell Biol 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: MCL1 (MCL1) → BAK/p53 complex (BAK1-TP53) (modification, collaborate)
  Leu et al., Nat Cell Biol 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: MCL1 (MCL1) → BAK/MCL1 complex (BAK1-MCL1) (modification, collaborate)
  Leu et al., Nat Cell Biol 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Direct p53 effectors: BAK/p53 complex (BAK1-TP53) → BAK/MCL1 complex (BAK1-MCL1) (modification, collaborate)
  Leu et al., Nat Cell Biol 2004*
  Evidence: mutant phenotype, physical interaction
• WikiPathways Apoptosis Modulation and Signaling: BAK1 → MCL1 (unknown)
• WikiPathways Apoptosis: BAK1 → BCL2L2/BCL2/BCL2L1/MCL1 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BAK1 — MCL1 (direct interaction, two hybrid) Bae et al., J Biol Chem 2000*
• IRef Biogrid Interaction: BAK1 — MCL1 (direct interaction, pull down) Warr et al., J Biol Chem 2011*
• IRef Biogrid Interaction: BAK1 — MCL1 (physical association, affinity chromatography technology) Stankiewicz et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: BAK1 — MCL1 (physical association, affinity chromatography technology) Willis et al., Genes Dev 2005*
• IRef Biogrid Interaction: BAK1 — MCL1 (physical association, affinity chromatography technology) Leu et al., Nat Cell Biol 2004*
• IRef Biogrid Interaction: BAK1 — MCL1 (direct interaction, pull down) Leu et al., Nat Cell Biol 2004*
• IRef Biogrid Interaction: BAK1 — MCL1 (direct interaction, unspecified method) Willis et al., Genes Dev 2005*
• IRef Biogrid Interaction: BAK1 — MCL1 (direct interaction, pull down) Weng et al., J Biol Chem 2005*
• MIPS CORUM MCL1-BAK1 complex: MCL1-BAK1 complex complex (BAK1-MCL1) Leu et al., Nat Cell Biol 2004*
• IRef Corum Interaction: BAK1 — MCL1 (association, coimmunoprecipitation) Leu et al., Nat Cell Biol 2004*
• IRef Dip Interaction: BAK1 — MCL1 (physical association, anti bait coimmunoprecipitation) Schwickart et al., Nature 2010*
• IRef Dip Interaction: BAK1 — MCL1 (physical association, anti bait coimmunoprecipitation) Nguyen et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: Complex of MCL1-BAK1-USP9X (anti bait coimmunoprecipitation) Schwickart et al., Nature 2010*
• IRef Intact Interaction: BAK1 — MCL1 (physical association, anti tag coimmunoprecipitation) Ménoret et al., FEBS Lett 2010*
• IRef Intact Interaction: BAK1 — MCL1 (physical association, anti bait coimmunoprecipitation) Willis et al., Genes Dev 2005*
• IRef Intact Interaction: BAK1 — MCL1 (physical association, anti tag coimmunoprecipitation) Willis et al., Genes Dev 2005*
• IRef Intact Interaction: BAK1 — MCL1 (physical association, anti bait coimmunoprecipitation) Konopleva et al., Cancer Cell 2006*
• IRef Intact Interaction: Complex of BBC3-BCL2L11-BCL2L11-MCL1-BAK1-MCL1-BBC3-BAK1 (association, anti bait coimmunoprecipitation) Wei et al., Cancer Cell 2012*
• IRef Intact Interaction: Complex of BAX-MCL1-BAK1 (association, anti tag coimmunoprecipitation) Ménoret et al., FEBS Lett 2010*
• IRef Intact Interaction: Complex of BAK1-PMAIP1-MCL1-BCL2L11 (association, anti bait coimmunoprecipitation) Zhang et al., Oncogene 2011*
• IRef Ophid Interaction: BAK1 — MCL1 (aggregation, confirmational text mining) Bae et al., J Biol Chem 2000*
• IRef Ophid Interaction: BAK1 — MCL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005