Gene interactions and pathways from curated databases and text-mining

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JAK3 — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Krasilnikov et al., Oncogene 2003 (Melanoma) : Tyrosine phosphorylation of STAT3/5 and of JAK2 also increased upon treatment of LU1205 cells with either PD or LY, suggesting that constitutive active MAPK and PI3K signals inhibit tyrosine phosphorylation of JAK/STATs
Luo et al., Eur J Neurosci 2007 (Optic Nerve Injuries) : In this study we showed that : ( i ) the RGC protection was pathway inhibition dependent ; ( ii ) inhibition of PI3K/akt and JAK/STAT , but not MEK/ERK, activated macrophages in the eye, ( iii ) macrophage removal from the eye using clodronate liposomes significantly impeded PI3K/akt and JAK/STAT inhibition induced RGC survival and axon regeneration whereas it only slightly affected MEK/ERK inhibition dependent protection ; ( iv ) in the absence of recruited macrophages in the eye, inhibition of PI3K/akt or JAK/STAT did not influence RGC survival ; and ( v ) strong PI3K/akt , JAK/STAT and MEK/ERK pathway activities were located in RGCs but not macrophages after ON injury
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Li et al., PloS one 2012 (Hypereosinophilic Syndrome) : Interestingly, JAK2 inhibition also reduced PI3K , Akt and NF-?B activity in a dose dependent manner, and suppressed expression levels of c-Myc and Survivin
Chang et al., Gen Comp Endocrinol 2012 : The specific inhibitors of either MEK1 ( U-0126 and PD-98059 ), JAK ( AG-490 ), JNK ( SP-600125 ), or PI3K ( LY-294002 and wortmannin ) reduced ET-1 increased levels of SOCS-3 mRNA and respectively inhibited ET-1 stimulated activities of MEK1, JAK, JNK, and PI3K