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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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IL3 — JAK3

Text-mined interactions from Literome

Yu et al., Oncogene 2003 : Further biochemical analyses revealed that IL-3 induced Jak/Stat , Erk, and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Pecaric-Petkovic et al., Blood 2009 (Hypersensitivity) : These effects are similar to that of IL-3, but the signaling pathways engaged are distinct because IL-33 strongly activates NF-kappaB and shows a preference for p38 MAP-kinase, while IL-3 acts through Jak/Stat and preferentially activates ERK
Kim et al., Molecular cancer 2010 : In addition, treatment of 32D/IL-2Rbeta cells with the compound led to a block in IL-2 dependent activation of JAK3/STAT5 but not IL-3 dependent activation of JAK2/STAT5