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FOXC2 — ITGB3

Text-mined interactions from Literome

Hayashi et al., J Biol Chem 2008 : We found that Itgb3 expression is directly regulated by Foxc2 through multiple Forkhead binding elements within two high homology regions in the Itgb3 promoter ... Because Itgb3 is known to regulate angiogenesis, we further tested whether Foxc2 is directly involved in angiogenesis by regulating Itgb3 expression by in vitro experiments ... Taken together, these results suggest that Foxc2 directly induces Itgb3 expression and regulates angiogenesis by Itgb3 mediated endothelial cell adhesion and migration
Hayashi et al., Cell Adh Migr 2009 (Neovascularization, Pathologic) : Recently, we reported that Forkhead transcription factor Foxc2 directly induces expression of the integrin beta3 subunit thorough Forkhead binding elements in its promoter, thereby regulating integrin beta3 mediated endothelial cell migration and adhesion