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IARS — IRS1
Text-mined interactions from Literome
Lee et al., Mol Endocrinol 1999
(Breast Neoplasms...) :
Estrogen induction of IGFR1 and
IRS expression
resulted in enhanced tyrosine phosphorylation of
IRS-1 after IGF-I stimulation, followed by enhanced mitogen activated protein kinase activation
Liu et al., J Biol Chem 1999
(Body Weight) :
The extent of tyrosine phosphorylation of IRS-1/2 following insulin stimulation was similar in adipocytes from IRS-3-null and wild-type mice, and the insulin induced association of tyrosine phosphorylated
IRS-1/2 with phosphatidylinositol 3-kinase and SHP-2 was not detectably
increased by
IRS-3 deficiency
Hemi et al., J Biol Chem 2002
(Insulin Resistance...) :
Similar to TNF, cycloheximide and anisomycin stimulated serine phosphorylation of
IRS-1 and IRS-2, reduced their ability to interact with the insulin receptor,
inhibited the insulin induced tyrosine phosphorylation of
IRS proteins, and diminished their association with phosphatidylinositol 3-kinase (PI3K)
Carvalheira et al., Endocrinology 2003
(Insulin Resistance...) :
AngII induced Janus kinase 2 tyrosine phosphorylation and coimmunoprecipitation with
insulin receptor substrate 1 (IRS-1) and IRS-2 as well as an
increase in tyrosine phosphorylation of
IRS and its association with growth factor receptor binding protein 2