Gene interactions and pathways from curated databases and text-mining

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IL4 — IRF4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Plander et al., Leukemia 2009 (Anemia...) : IL-4 increased interferon regulatory factor-4 expression and induced a specific immunophenotype, which may imply plasmacytic differentiation
Shindo et al., Cytokine 2011 : Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel ... We also demonstrated that IL-2 production was also enhanced by exogenously expressed IRF-4 and c-Rel in the presence of P/I, in T-cells, and that the optimal IL-2 and IL-4 productions in vivo was IRF-4 dependent using IRF-4-/- mice