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CD14 — IL9
Text-mined interactions from Literome
Iwagaki et al., Infect Immun 2000
:
The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit
CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines,
interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Pilette et al., Eur Respir J 2002
:
However, several observations suggested that IL-9 and IL-4 act through different mechanisms : 1 ) interferon-gamma antagonised the IL4- but not the IL-9 mediated inhibition of AM oxidative burst ; 2 ) expression of
CD14 was downregulated by IL-4 but not by IL-9 and 3 ) production of tumour growth factor-beta by activated AM was
potentiated by
IL-9 and not by IL4, and was required for the IL-9 mediated inhibition of AM oxidative burst