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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to IL2RG
IL2RG — RHOA
Pathways - manually collected, often from reviews:
NCI Pathway Database SHP2 signaling :
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000 , Gu et al., Mol Cell Biol 2000 , Merida et al., J Immunol 1991 , Truitt et al., J Biol Chem 1994 , Kanazawa et al., Cell Immunol 1994 , Gómez et al., J Immunol 1997
mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events :
RHOA/GTP complex (RHOA)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11)
(modification, activates)
Gadina et al., J Biol Chem 2000 , Gu et al., Mol Cell Biol 2000 , Merida et al., J Immunol 1991 , Truitt et al., J Biol Chem 1994 , Kanazawa et al., Cell Immunol 1994 , Gómez et al., J Immunol 1997 , Gadina et al., J Immunol 1999
mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events :
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Gómez et al., J Immunol 1997
mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events :
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Gómez et al., J Immunol 1997
mutant phenotype, other species