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IL18 — IL18BP

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL18 → IL18BP (decreases)
  Evidence: from full text - this pleiotropic proinflammatory cytokine (IL18) and its natural inhibitor, IL-18- binding protein (IL-18BP)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IL18 — IL18BP (direct interaction, pull down) Corbaz et al., J Immunol 2002*
• IRef Hprd Interaction: IL18 — IL18BP (in vivo) Corbaz et al., J Immunol 2002*
• IRef Hprd Interaction: IL18 — IL18BP (in vitro) Corbaz et al., J Immunol 2002*
• IRef Innatedb Interaction: IL18 — IL18BP (unknown, -) Bufler et al., Proc Natl Acad Sci U S A 2002*
• IRef Innatedb Interaction: IL18 — IL18BP (unknown, -) Xiang et al., J Biol Chem 2001*
• IRef Innatedb Interaction: IL18 — IL18BP (unknown, -) Corbaz et al., J Immunol 2002*
• IRef Innatedb Interaction: IL18 — IL18BP (unknown, -) Kim et al., Proc Natl Acad Sci U S A 2000*
• IRef Innatedb Interaction: IL18 — IL18BP (unknown, -) Aizawa et al., FEBS Lett 1999*
• IRef Innatedb Interaction: IL18 — IL18BP (unknown, -) Novick et al., Immunity 1999*
• IRef Ophid Interaction: IL18 — IL18BP (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Fantuzzi et al., Eur J Immunol 2001 : In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Pomerantz et al., Proc Natl Acad Sci U S A 2001 (Myocardial Ischemia) : Addition of IL-18 binding protein (IL-18BP) , the constitutive inhibitor of IL-18 activity, to the perifusate during and after I/R resulted in improved contractile function after I/R from 35 % of control to 76 % with IL-18BP
Yatsiv et al., J Cereb Blood Flow Metab 2002 (Brain Injuries...) : Published data imply that IL-18 may play a pathophysiological role in inflammatory CNS diseases ; therefore its inhibition may ameliorate outcome after CHI. To evaluate the functional aspects of IL-18 in the injured brain, mice were injected systemically with IL-18 binding protein (IL-18BP) , a specific inhibitor of IL-18 , 1 hour after trauma
Dinarello et al., Blood Purif 2003 (Kidney Failure, Chronic) : The activity of IL-18 can be regulated by the IL-18 binding protein (IL-18BP) , a glycoprotein of 40,000 daltons, which is constitutively expressed and appears to be the natural inhibitor of IL-18 activity
Lonnemann et al., Clin Nephrol 2003 (Kidney Failure, Chronic) : We investigated the influence of kidney function on plasma levels of interleukin-18 binding protein (IL-18BP) , the naturally occurring inhibitor of IL-18
Kawashima et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : The production of IL-18BP in response to IL-12 and IL-18 was regulated differently in blood and synovial cells
Swencki-Underwood et al., Cytokine 2006 : The IL-18 variants were inhibited by IL-18 binding protein (IL-18BP) , the soluble inhibitor of IL-18 , as measured by neutralization of the IFNgamma response in PBMCs
Sifringer et al., Neurobiol Dis 2007 (Brain Injuries...) : Intraperitoneal injection of recombinant human IL-18 binding protein (IL-18BP) , a specific inhibitor of IL-18 , attenuated traumatic brain injury
Kimura et al., Allergol Int 2008 (Hypersensitivity) : The structural mechanism of IL-18BP inhibition might be a competition for Site 2 on rIL-18 so that IL-18BP can prevent IL-18 receptor alpha from binding to Site 2 and inhibit IL-18 receptor activation
Novick et al., J Autoimmun 2010 (Disease Progression...) : High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein
Millward et al., J Immunol 2010 (Encephalomyelitis, Autoimmune, Experimental...) : We show in this study that IL-18 binding protein (IL-18bp) , the endogenous inhibitor of the Th1 promoting cytokine IL-18 , is upregulated by IFN-gamma in resident microglial cells in the CNS during multiple sclerosis-like disease in mice
Fujita et al., Int J Cancer 2011 (Prostatic Neoplasms) : A cytokine antibody array was previously applied to prostatic fluid obtained from patients with prostate cancer, and interleukin 18 binding protein (IL-18BP) , a potent inhibitor of interleukin 18 , was noted to be significantly upregulated in cases with large volume disease ... The IL-18BP secreted from DU145 and PC3 functionally inhibited IL-18
Murray et al., J Mol Cell Cardiol 2012 (Cardiomegaly) : IL-18 binding protein (IL-18BP) , a natural inhibitor of IL-18 , counters its biological effects
Carbotti et al., Clin Cancer Res 2013 : Together, these data indicate that IL-18BP , which is produced in EOC in response to microenvironmental factors, may inhibit endogenous or exogenous IL-18 activity