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IKBKB — MAP3K3

Pathways - manually collected, often from reviews:

• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → Complex of IKBKG-CHUK-IKBKB-HSP90AA1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: IKBKB — MAP3K3 (in vitro) Yang et al., Nat Immunol 2001
• IRef Innatedb Interaction: IKBKB — MAP3K3 (unknown, -) Blonska et al., Mol Cell Biol 2004*
• IRef Intact Interaction: IKBKB — MAP3K3 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Ophid Interaction: IKBKB — MAP3K3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Zhao et al., J Biol Chem 1999 : The essential features of this cascade are that a mitogen activated protein kinase kinase kinase ( MAP3K ) activates an IkappaB kinase (IKK) that site-specifically phosphorylates IkappaB ... We now show that MEKK2 and MEKK3 can in vivo activate IKK-alpha and IKK-beta , induce site-specific IkappaBalpha phosphorylation, and, relatively modestly, activate an NF-kappaB reporter gene
Yang et al., Nat Immunol 2001 : We have shown that MEKK3 is required for IKK activation and functions downstream of receptor interacting protein ( RIP ) and TNF receptor- associated factor 2
Sun et al., Cell Signal 2009 : Together, our results provide the genetic evidence that MEKK3 but not TAK1 is required for LPA receptor mediated IKK-NF-kappaB activation