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ANGPT2 — HSPG2

Text-mined interactions from Literome

Freeman et al., Arch Biochem Biophys 1995 : Furthermore, these data suggest that Ang II stimulation of PLD may occur subsequent to activation of PLC, since Ang II activates PLC and PLC is shown to be responsible for increases in intracellular Ca2- in response to Ang II
Freeman et al., Biochem J 1994 : Alternatively, PLD may be sequentially activated in response to Ang II activation of PLC and a subsequent increase in calcium concentration
Marrero et al., Am J Physiol 1996 : 1 ) Stimulation of inositol phosphate hydrolysis by PLC , release of IP3 dependent intracellular Ca2+ stores, and activation of Ca ( 2+ ) -dependent C1-channels by ANG II are dependent on the tyrosine phosphorylation of PLC-gamma 1.2 ) This ANG II-induced signal transduction cascade provides a possible mechanism for both the contractile and growth stimulating effects of ANG II on glomerular mesangial cells
Tallant et al., Glia 1997 : In medullary and cerebellar astrocytes, Ang II activated a phosphoinositide-specific PLC in a dose dependent manner with EC50s of 1.74 and 1.86 nM, respectively ... In contrast, Ang II did not activate PLC or release prostaglandins in astrocytes isolated from the cortex or hypothalamus
Schmitz et al., Circ Res 1997 : We have previously shown that in rat aortic smooth muscle ( RASM ) cells Ang II stimulates tyrosine phosphorylation of PLC-gamma via activation of c-Src
Amlal et al., Am J Physiol 1998 : Thus < or = 10 ( -12 ) M ANG II inhibits via 20-HETE, whereas > or = 5 x 10 ( -11 ) M ANG II stimulates via PKC Na ( + ) -K+ ( NH4+ ) -2Cl- cotransport ; all ANG II effects involve AT1 receptors and PLC activation
Côté et al., Endocr Res 1998 : According to classic studies, Ang II and AVP activate phospholipase C (PLC) , diacylglycerol ( DAG ) and inositol phosphate ( InsPs ) production whereas ACTH activates cAMP production