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HRG — PXN

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Vadlamudi et al., Cancer Res 1999 (Breast Neoplasms) : Because the process of cell migration must involve dynamic changes in the formation of new focal adhesions at the leading edge and dissolution of preexisting focal points, we explored the potential HRG regulation of paxillin , a major component of focal adhesion
Vadlamudi et al., Oncogene 1999 (Breast Neoplasms) : Since the process of cell migration must involve changes in adhesion, we explored the potential HRG regulation of paxillin , a major cytoskeletal phosphoprotein of focal adhesion ... We report that HRG stimulation of non-invasive breast cancer cells resulted in stimulation of p38 mitogen activated protein kinase ( p38MAPK ), extracellular signal regulated kinases ( ERK ) and PI-3K, and a concurrent unexpected increase in the level of paxillin phosphorylation on serine residue which was sensitive to protein-phosphatase 2b but not to protein tyrosine phosphatase 1 ... The HRG induced increase in serine phosphorylation of paxillin and cell scattering were selectively inhibited by a specific inhibitor of p38MAPK or a dominant negative p38MAPK mutant, but not by inhibitors of p42/44MAPK or PI-3 kinase pathways