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Porcelli et al., Biochim Biophys Acta 2002
(Osteosarcoma) :
It is concluded that, although overexpression of P-glycoprotein did not impair pH(i) regulation in U-2 OS cells, the kinetic parameters of the Na ( + ) /H ( + ) exchanger were altered, suggesting a functional relationship between the two membrane proteins
Schwamberger et al., Int Immunol 1992
(Neoplasms) :
Expression of this glycoprotein was strongly dependent on activation of BMM phi by a combination of IFN-gamma and LPS but was only marginally induced by either stimulant alone
Keizer et al., J Natl Cancer Inst 1989
(Lung Neoplasms) :
These data suggest that, in the absence of xenobiotic substrates, P-glycoprotein activity can affect cellular pHi