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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to GNAI1
GNAI1 — GNAO1
Pathways - manually collected, often from reviews:
NCI Pathway Database Endothelins :
Gai/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
ETB receptor/Endothelin-1/Gi/GTP complex (EDNRB-EDN1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
NCI Pathway Database Nongenotropic Androgen signaling :
Gi family/GNB1/GNG2/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2)
→
Gi family/GTP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Sun et al., J Androl 2006 , Steinsapir et al., Biochem Biophys Res Commun 1991
mutant phenotype
NCI Pathway Database S1P3 pathway :
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
→
S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
NCI Pathway Database CXCR3-mediated signaling events :
Gi family/GNB1/GNG2/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2)
→
Gi family/GTP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Mueller et al., J Leukoc Biol 2008
assay
NCI Pathway Database S1P5 pathway :
S1P/S1P5/Gi complex (S1PR5-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
(modification, collaborate)
mutant phenotype, assay, physical interaction
NCI Pathway Database S1P1 pathway :
S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
(modification, collaborate)
Van Brocklyn et al., J Cell Biol 1998
mutant phenotype, assay, physical interaction
NCI Pathway Database Hedgehog signaling events mediated by Gli proteins :
Gi family/GNB1/GNG2/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2)
→
Gi family/GTP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Riobo et al., Proc Natl Acad Sci U S A 2006
mutant phenotype, assay, other species
NCI Pathway Database S1P4 pathway :
S1P/S1P5/Gi complex (S1PR5-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
(modification, collaborate)
Gräler et al., J Cell Biochem 2003
mutant phenotype, assay, physical interaction
NCI Pathway Database Plasma membrane estrogen receptor signaling :
Gai/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
ER alpha/Gai/GDP/Gbeta gamma complex (ESR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2)
(modification, collaborate)
Wyckoff et al., J Biol Chem 2001 , Lu et al., Proc Natl Acad Sci U S A 2004 , Kumar et al., Mol Endocrinol 2007
mutant phenotype, physical interaction
NCI Pathway Database S1P4 pathway :
S1P/S1P4/Gi complex (S1PR4-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
(modification, collaborate)
Gräler et al., J Cell Biochem 2003
mutant phenotype, assay, physical interaction
NCI Pathway Database S1P2 pathway :
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
→
S1P/S1P2/Gi complex (S1PR2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
NCI Pathway Database Nongenotropic Androgen signaling :
Gi family/GNB1/GNG2/GDP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2)
→
Gi family/GTP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, collaborate)
Lieberherr et al., J Biol Chem 1994
other species
NCI Pathway Database Sphingosine 1-phosphate (S1P) pathway :
S1P/S1P4/Gi complex (S1PR4-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
(modification, collaborate)
Gräler et al., J Cell Biochem 2003
mutant phenotype, assay, physical interaction
NCI Pathway Database S1P3 pathway :
S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
S1P/S1P2/Gi complex (S1PR2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(angiogenesis, collaborate)
Kono et al., J Biol Chem 2004
mutant phenotype, assay
NCI Pathway Database S1P3 pathway :
S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(angiogenesis, collaborate)
Kono et al., J Biol Chem 2004
mutant phenotype, assay
NCI Pathway Database S1P3 pathway :
S1P/S1P2/Gi complex (S1PR2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(angiogenesis, collaborate)
Kono et al., J Biol Chem 2004
mutant phenotype, assay
NCI Pathway Database LPA receptor mediated events :
Gi(beta/gamma) complex (GNB1-GNG2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
→
Gi family (GNAI2/GNAI3/GNAO1/GNAO1/GNAZ/GNAI1)
(modification, collaborate)
Fukushima et al., Proc Natl Acad Sci U S A 1998
assay, other species, functional complementation
Reactome Reaction :
GNAO1
→
GNAI1
(reaction)
Oldham et al., Nature structural & molecular biology 2006 , Kleuss et al., Proc Natl Acad Sci U S A 1994 , Coleman et al., Science 1994
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Gene Ontology Complexes heterotrimeric G-protein complex :
heterotrimeric G-protein complex complex (GNAO1-GNAT1-GNAT3-GNAT2-GNAI2-GNAI3-GNAI1-GNA14-GNG10-GNG11-GNG12-GNG13-RGS6-RGS7-RGS9-GNG3-GNB1-GNAQ-GNAZ-RGS19-GNG7-GNG4-GNG5-GNG2-GNGT2-GNGT1-GNA11-GNA13-GNG8)
Huang et al., Nat Neurosci 1999 , Kubo et al., FEBS Lett 1991 , Wilkie et al., Proc Natl Acad Sci U S A 1991 , Lerea et al., Neuron 1989 , Bray et al., Proc Natl Acad Sci U S A 1987 , De Vries et al., Proc Natl Acad Sci U S A 1995 , Ong et al., Genomics 1997 , Liu et al., Biochem Biophys Res Commun 1998
IRef Hprd Interaction :
Complex of FFAR3-GNAI1-GNAO1-FFAR3-GNAO1-FFAR3-GNAI1-GNAO1-GNAI1
(in vivo)
Le Poul et al., J Biol Chem 2003 *
IRef Hprd Interaction :
Complex of 101 proteins
(in vivo)
Laugwitz et al., Proc Natl Acad Sci U S A 1996
IRef Hprd Interaction :
GNAI1
—
GNAO1
(in vivo)
Yeo et al., J Neurochem 2001 *
IRef Hprd Interaction :
Complex of GNAO1-FFAR2-GNAO1-GNAI1-FFAR2-FFAR2-GNAI1-GNAO1-GNAI1
(in vivo)
Le Poul et al., J Biol Chem 2003 *
STRING interaction :
GNAI1
—
GNAO1
(interaction, mapped from reactome)
STRING interaction :
GNAO1
—
GNAI1
(interaction, mapped from reactome)