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FGF2 — SMC5

Text-mined interactions from Literome

Myllärniemi et al., Cardiovasc Drugs Ther 1999 : Administration of the PDGF-R tyrosine kinase inhibitor in vivo, tested and found to inhibit the proliferation of SMC induced by PDGF-AA and PDGF-BB, but not by IGF-1, EGF, or bFGF , resulted in a 60 % reduction in the absolute number and percentage of BrdU + cells after the second balloon injury to pre existing neointima, but had no significant effect on proliferation after the first injury
Facchiano et al., J Cell Sci 2000 : These in vitro studies show that bFGF significantly inhibits PDGF-BB induced SMC migration and proliferation and that this effect is mediated by both PDGF-Ralpha and bFGF receptor
Carreras et al., J Cell Biochem 2002 : The addition of PD-98059, an inhibitor of ERK1/2 kinase, abrogates the bFGF dependent decrease of elastin mRNA in SMC
Xu et al., Atherosclerosis 2002 : Staurosporine, an inhibitor of protein kinase C ( PKC ), inhibited proliferation of SMC induced by bFGF , and both bFGF- and S1P induced proliferation of SMC was sensitive to pertussis toxin ( PTX ), an inhibitor of Gi-protein activity
Kinsella et al., Atherosclerosis 2004 (Carotid Artery Injuries) : In this study, a model of FGF-2 dependent medial SMC mitogenic response in balloon injured rat carotid artery was used to test the effect of degradation of vessel wall heparan sulfate on subsequent SMC proliferation
Kawai-Kowase et al., Arterioscler Thromb Vasc Biol 2004 : In the presence of bFGF , TGFbeta1 induction of SMC marker gene expression was significantly attenuated ... Mitogen activated protein kinase kinase-1 ( MEK1 ) inhibitor PD98059 abrogated the bFGF mediated suppression of TGFbeta1 induced SMC gene expression ... These data indicate that opposing effects of bFGF and TGFbeta1 on SMC gene expression control the phenotypic plasticity of SMCs
Camozzi et al., Arterioscler Thromb Vasc Biol 2005 (Carotid Artery Injuries...) : We investigated the capacity of PTX3 to affect FGF2 dependent SMC activation in vitro and in vivo
Nakahara et al., Biochem Biophys Res Commun 2010 (Atherosclerosis) : Stimulation of cultured rat aortic SMC ( RASMC ) with FGF-2 induced the expression of the osteoblastic markers osteopontin (OPN) and osteocalcin
Yoshida et al., International journal of biological sciences 2012 : In addition, the TGF-ß1 induced SMC markers expression of the PDL derived cells was reversed upon stimulation with fibroblast growth factor ( FGF ) , suggesting that the TGF-ß1 might not induce terminal SMC differentiation of the EPC-like fibroblastic cells
Michiels et al., Exp Cell Res 1994 : Finally, the mitogenic effects of PGF2 alpha and of bFGF on SMC are additive
Allera et al., C R Acad Sci III 1996 : Regulation of proliferation and migration are well known roles of fibroblast growth factor 2 (FGF-2) for arterial smooth muscle cells ( SMC )
Wang et al., Am J Physiol 1997 : IL-4 plus bFGF resulted in a net increase in SMC fibrinolytic activity
Chen et al., J Surg Res 1997 (Hyperplasia) : At a dose of 10 ng/mL, bFGF significantly promoted both SMC and EC proliferation ( 7- and 4-fold, respectively ) and migration ( 2.3- and 1.9-fold, respectively )
Kypreos et al., J Cell Biochem 1998 : Here we have investigated the effects of bFGF on aortic SMC expression of type V/XI collagen