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EED — PHF1

Pathways - manually collected, often from reviews:

• Reactome Reaction: PHF1 → EED (indirect_complex)
• Reactome Reaction: PHF1 → EED (reaction) Cao et al., Science 2002, Kuzmichev et al., Genes Dev 2002, Kuzmichev et al., Mol Cell 2004, Martin et al., J Biol Chem 2006, Margueron et al., Mol Cell 2008, McCabe et al., Proc Natl Acad Sci U S A 2012, Swalm et al., Biochem J 2013

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PHF1 — EED (physical association, affinity chromatography technology) Sarma et al., Mol Cell Biol 2008*

Text-mined interactions from Literome

Cao et al., Mol Cell Biol 2008 : Consistent with the ability of hPHF1 to stimulate the enzymatic activity of the core EED-EZH2 complex in vitro, manipulation of mPcl1, the mouse counterpart of hPHF1, in NIH 3T3 cells and cells of the mouse male germ cell line GC1spg results in global alteration of H3K27me2 and H3K27me3 levels and Hox gene expression
Cai et al., Mol Cell 2013 : Ectopically expressed PHF1 induced Tudor dependent stabilization of PRC2 complexes on bulk chromatin and mediated spreading of PRC2 and H3K27me3 into H3K36me3 containing chromatin regions