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DOK1 — RASA1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK complex (INPP5D-RASA1-DOK1-FCER1G-MS4A2-FCGR2B-FCER1A) → HRAS/GTP complex (HRAS) (modification, inhibits)
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) (modification, activates)
  Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → HRAS/GTP complex (HRAS) (modification, inhibits) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → HRAS/GDP complex (HRAS) (modification, inhibits) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → JNK1 (MAPK8) (modification, activates) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK complex (INPP5D-RASA1-DOK1-FCER1G-MS4A2-FCGR2B-FCER1A) → Fc epsilon R1/FcgammaRIIB/SHIP complex (INPP5D-FCGR2B-MS4A2-FCER1G-FCER1A) (modification, collaborate)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK complex (INPP5D-RASA1-DOK1-FCER1G-MS4A2-FCGR2B-FCER1A) → RasGAP/p62DOK complex (RASA1-DOK1) (modification, collaborate)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Fc epsilon R1/FcgammaRIIB/SHIP complex (INPP5D-FCGR2B-MS4A2-FCER1G-FCER1A) → RasGAP/p62DOK complex (RASA1-DOK1) (modification, collaborate)
  
• NCI Pathway Database BCR signaling pathway: None → RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) (modification, collaborate)
  Yamanashi et al., Genes Dev 2000, Teixeira et al., Blood 2003, Kumar et al., Biochem J 1995, Hashimoto et al., J Exp Med 1998
• NCI Pathway Database BCR signaling pathway: RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) → SHC/Grb2/SOS1 complex (SOS1-GRB2-SHC1) (modification, inhibits)
  Yamanashi et al., Genes Dev 2000, Teixeira et al., Blood 2003, Kumar et al., Biochem J 1995, Hashimoto et al., J Exp Med 1998
• NCI Pathway Database BCR signaling pathway: RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) → None (modification, inhibits) Yamanashi et al., Genes Dev 2000, Teixeira et al., Blood 2003, Kumar et al., Biochem J 1995, Hashimoto et al., J Exp Med 1998
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RasGAP (RASA1) → RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RasGAP (RASA1) → RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → NCK1 (NCK1) (modification, collaborate) Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Insulin Pathway: RasGAP (RASA1) → p62DOK/RasGAP complex (DOK1-RASA1) (modification, collaborate)
  Wick et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: RasGAP (RASA1) → p62DOK (DOK1) (modification, collaborate) Wick et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: RasGAP (RASA1) → p62DOK/RasGAP complex (DOK1-NCK1) (modification, collaborate)
  Wick et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: p62DOK/RasGAP complex (DOK1-RASA1) → p62DOK (DOK1) (modification, collaborate) Wick et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: p62DOK/RasGAP complex (DOK1-RASA1) → NCK1 (NCK1) (modification, collaborate) Wick et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: p62DOK/RasGAP complex (DOK1-RASA1) → p62DOK/RasGAP complex (DOK1-NCK1) (modification, collaborate)
  Wick et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database BCR signaling pathway: RasGAP (RASA1) → RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) (modification, collaborate)
  Tamir et al., Immunity 2000
• NCI Pathway Database BCR signaling pathway: RasGAP (RASA1) → p62DOK (DOK1) (modification, collaborate) Tamir et al., Immunity 2000
• NCI Pathway Database BCR signaling pathway: RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) → p62DOK (DOK1) (modification, collaborate) Tamir et al., Immunity 2000
• NCI Pathway Database BCR signaling pathway: RasGAP/p62DOK/SHIP complex (RASA1-DOK1-INPP5D) → SHIP (INPP5D) (modification, collaborate) Tamir et al., Immunity 2000
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: None → RasGAP/p62DOK complex (RASA1-DOK1) (modification, activates)
  Hiragun et al., Mol Pharmacol 2005*
  Evidence: assay
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: RasGAP (RASA1) → RasGAP/p62DOK complex (RASA1-DOK1) (modification, collaborate)
  Hiragun et al., Mol Pharmacol 2005*
  Evidence: assay
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: RasGAP (RASA1) → p62DOK (DOK1) (modification, collaborate) Hiragun et al., Mol Pharmacol 2005*
  Evidence: assay
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: RasGAP/p62DOK complex (RASA1-DOK1) → p62DOK (DOK1) (modification, collaborate) Hiragun et al., Mol Pharmacol 2005*
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: DOK1 — RASA1 Dunant et al., Cell Signal 2000*
• IRef Bind_translation Interaction: DOK1 — RASA1 (coimmunoprecipitation) Dunant et al., Cell Signal 2000*
• IRef Biogrid Interaction: DOK1 — RASA1 (direct interaction, pull down) Kashige et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Dunant et al., Cell Signal 2000*
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Yamanashi et al., Cell 1997*
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Némorin et al., J Biol Chem 2000*
• IRef Biogrid Interaction: DOK1 — RASA1 (direct interaction, unspecified method) Liu et al., Cell communication and signaling : CCS 2012
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Di Cristofano et al., J Biol Chem 1998*
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Bhat et al., J Biol Chem 1998*
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Wick et al., J Biol Chem 2001
• IRef Biogrid Interaction: DOK1 — RASA1 (physical association, affinity chromatography technology) Kashige et al., Proc Natl Acad Sci U S A 2000*
• IRef Hprd Interaction: DOK1 — RASA1 (in vitro) Yamanashi et al., Cell 1997*
• IRef Ophid Interaction: DOK1 — RASA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kashige et al., Proc Natl Acad Sci U S A 2000 : Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity
Abramson et al., Eur J Immunol 2003 : This modification of Dok-1 increases its association with RasGAP , suggesting that it is modulating Ras activity
Zhao et al., Mol Cell Biol 2006 : On the other hand, Dok-1 negatively regulates PDGF induced MAPK activation by acting on Ras-GAP and at least one other Dok-1 interacting protein