◀ Back to CYP7A1
CYP7A1 — FGF8
Text-mined interactions from Literome
Kurosu et al., J Biol Chem 2007
:
Accordingly,
FGF19 , but not FGF21, activates FGF signaling in hepatocytes that primarily express FGFR4 and
reduces transcription of
CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kim et al., J Lipid Res 2007
:
Consistent with these findings, recombinant
FGF15 repressed
CYP7A1 mRNA levels without affecting CYP8B1 expression
Slätis et al., J Lipid Res 2010
(Atherosclerosis) :
The upregulation of
Cyp7a1 in DKO mice seemed primarily
caused by reduced expression of the intestinal peptide
FGF15
Csanaky et al., Hepatology 2011
:
Increased expression of
fibroblast growth factor 15 in intestines of Oatp1b2-null mice might be
responsible for decreased hepatic expression of
Cyp7a1 in Oatp1b2-null mice
Kong et al., Hepatology 2012
:
However, deficiency of both ERK and JNK pathways prevented
Fgf15 mediated suppression of
Cyp7a1 and Cyp8b1 gene expression