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CDK7 — POLR2B

Pathways - manually collected, often from reviews:

• Reactome Reaction: POLR2B → CDK7 (reaction) Tirode et al., Mol Cell 1999, Fiedler et al., Bioessays 2000, Fiedler et al., Nucleic Acids Res 2001, Pal et al., Mol Cell Biol 2001, Pal et al., Mol Cell Biol 2002, Wang et al., Science 1992, Jacob et al., J Biol Chem 1991, Bunick et al., Cell 1982, Zawel et al., Genes Dev 1995, Goodrich et al., Cell 1994, Parvin et al., Cell 1993, Orphanides et al., Genes Dev 1996, Dvir et al., Proc Natl Acad Sci U S A 1997, Dvir et al., J Biol Chem 1997, Holstege et al., EMBO J 1997, Yamada-Okabe et al., Nucleic Acids Res 1998, Tsukamoto et al., Biochem Biophys Res Commun 1998
• Reactome Reaction: POLR2B → CDK7 (indirect_complex) Fiedler et al., Nucleic Acids Res 2001, Pal et al., Mol Cell Biol 2001, Kugel et al., Mol Cell Biol 2002, Conaway et al., J Biol Chem 1988, Zawel et al., Genes Dev 1995, Orphanides et al., Genes Dev 1996, Dvir et al., J Biol Chem 1997, Holstege et al., EMBO J 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: POLR2B — CDK7 (direct interaction, enzymatic study) Cujec et al., Genes Dev 1997*
• IRef Ophid Interaction: POLR2B — CDK7 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yamamoto et al., Mol Cell Biol 2001 : Here we demonstrate for the first time that TFIIH mediated phosphorylation of RNA polymerase II (Pol II) is essential for the transition to elongation
Schwartz et al., Mol Cell Biol 2003 : Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo
Giglia-Mari et al., PLoS Biol 2006 : Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair ( NER )
Węsierska-Gądek et al., J Cell Biochem 2011 (Breast Neoplasms...) : This inhibition of site-specific modification of CDK7 at Ser164/170 prevented phosphorylation of RNA polymerase II and reduced basal phosphorylation of ER-a at Ser118 in non stimulated MCF-7 cells ( resulting in its down-regulation )
Manzo et al., Cancer Res 2012 (Neoplasms) : Natural product triptolide mediates cancer cell death by triggering CDK7 dependent degradation of RNA polymerase II
Dvir et al., J Biol Chem 1996 : A role for ATP and TFIIH in activation of the RNA polymerase II preinitiation complex prior to transcription initiation
Dvir et al., Proc Natl Acad Sci U S A 1997 : In this report, we present direct evidence that TFIIH also controls RNA polymerase II activity at a postinitiation stage of transcription, by preventing premature arrest by very early elongation complexes just prior to their transition to stably elongating complexes