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CDC25C — PLK1

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: PLK1 → CDC25B/CDC25C (protein-protein, phosphorylation)
• KEGG Oocyte meiosis: PLK1 → CDC25C (protein-protein, activation)
• KEGG Progesterone-mediated oocyte maturation: PLK1 → CDC25A/CDC25B/CDC25C (protein-protein, activation)
• Reactome Reaction: PLK1 → CDC25C (reaction) Toyoshima-Morimoto et al., EMBO Rep 2002*
• WikiPathways Cell Cycle: PLK1 → CDC25B/CDC25C (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: PLK1 — CDC25C (experimental interaction detection) Gumireddy et al., Cancer Cell 2005*
• IRef Biogrid Interaction: PLK1 — CDC25C (physical association, affinity chromatography technology) Izumi et al., Oncogene 2009*
• IRef Biogrid Interaction: PLK1 — CDC25C (direct interaction, enzymatic study) Izumi et al., Oncogene 2009*
• IRef Biogrid Interaction: PLK1 — CDC25C (physical association, affinity chromatography technology) Yun et al., Nature structural & molecular biology 2009*
• IRef Biogrid Interaction: PLK1 — CDC25C (direct interaction, enzymatic study) Roshak et al., Cell Signal 2000*
• IRef Dip Interaction: CDC25C — PLK1 (physical association, anti bait coimmunoprecipitation) Yun et al., Nature structural & molecular biology 2009*
• IRef Dip Interaction: CDC25C — PLK1 (physical association, pull down) Yun et al., Nature structural & molecular biology 2009*
• IRef Hprd Interaction: PLK1 — CDC25C (in vitro) Roshak et al., Cell Signal 2000*, Toyoshima-Morimoto et al., EMBO Rep 2002*, Elia et al., Science 2003*, Elia et al., Cell 2003*, Chen et al., FEBS Lett 2006*
• IRef Hprd Interaction: PLK1 — CDC25C (in vivo) Roshak et al., Cell Signal 2000*, Toyoshima-Morimoto et al., EMBO Rep 2002*, Elia et al., Science 2003*, Elia et al., Cell 2003*, Chen et al., FEBS Lett 2006*
• IRef Intact Interaction: CDC25C — PLK1 (direct interaction, pull down) Elia et al., Science 2003*
• IRef Intact Interaction: CDC25C — PLK1 (physical association, coimmunoprecipitation) Elia et al., Science 2003*
• IRef Intact Interaction: CDC25C — PLK1 (physical association, anti tag coimmunoprecipitation) Elia et al., Cell 2003*
• IRef Ophid Interaction: CDC25C — PLK1 (aggregation, confirmational text mining) Roshak et al., Cell Signal 2000*
• IRef Ophid Interaction: CDC25C — PLK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Toyoshima-Morimoto et al., EMBO Rep 2002 : Plk1 promotes nuclear translocation of human Cdc25C during prophase
Liu et al., Proc Natl Acad Sci U S A 2002 : Plks have been reported to mediate multiple mitotic processes, including bipolar spindle formation, activation of Cdc25C , actin ring formation, centrosome maturation, and activation of the anaphase promoting complex
Rivers et al., J Cell Biol 2008 : PLK-1 shows anterior cytoplasmic enrichment and CDC-25.1 shows PLK-1 dependent enrichment in the anterior nucleus