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CCND2 — CDK4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CCND2-CDK4 (increases)
  Evidence: E2 enhanced proliferation, bromodeoxyuridine incorporation of keratinocytes, and increased the proportion of cells in the S phase. The E2-induced stimulation of proliferation and bromodeoxyuridine incorporation was suppressed by antisense oligonucleotide against cyclin D2, which induces G1 to S phase progression. E2 increased protein and mRNA levels of cyclin D2, and resultantly enhanced assembly and kinase activities of cyclin D2-cyclin-dependent kinases 4 or 6 complexes.
• OpenBEL Selventa BEL large corpus: Complex of CCND2-CDK4-CDKN1B → MYC (increases) Bouchard et al., EMBO J 1999
  Evidence: We nowshow that p27 is rapidly and transiently sequestered by cyclin D2-Cdk4 complexesupon activation of Myc and that cyclin D2 is a direct target gene of Myc.
• BioCarta cyclins and cell cycle regulation: RB/E2F-1 complex (E2F1-RB1) → CDK4/cyclin D2 complex (CDK4-CCND2) (modification, collaborate)
  
• BioCarta cyclins and cell cycle regulation: CDK4/cyclin D2 complex (CDK4-CCND2) → RB (RB1) (modification, activates)
• BioCarta cyclins and cell cycle regulation: p14arf (CDKN2A) → CDK4/cyclin D2 complex (CDK4-CCND2) (modification, activates)
  
• KEGG Cell cycle: CDKN1B/CDKN1C → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: PCNA → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2B → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RBL1/RBL2 (protein-protein, inhibition)
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RB1 (protein-protein, inhibition)
• KEGG Cell cycle: CDKN2A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2C → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2D → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG p53 signaling pathway: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → HDAC1 (HDAC1) (modification, inhibits) Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, inhibits)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: p16INK4a (CDKN2A) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: p16INK4a (CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• WikiPathways Signaling Pathways in Glioblastoma: MAPK1/MAPK3 → Complex of CCND1-CCND2-CDK4 (mim-stimulation)
  
• WikiPathways Signaling Pathways in Glioblastoma: CDKN2A/CDKN2C/CDKN2B → Complex of CCND1-CCND2-CDK4 (mim-inhibition)
  
• WikiPathways Signaling Pathways in Glioblastoma: CDKN1A → Complex of CCND1-CCND2-CDK4 (mim-inhibition)
  
• WikiPathways Signaling Pathways in Glioblastoma: Complex of CCND1-CCND2-CDK4 → RB1 (mim-inhibition)
• WikiPathways miRNA Regulation of DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways miRNA Regulation of DNA Damage Response: CDC25A → Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 (activation)
  
• WikiPathways DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways DNA Damage Response: CDC25A → Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CCND2 — CDK4 Murai et al., Int J Cancer 2001*
• IRef Bind_translation Interaction: CCND2 — CDK4 (coimmunoprecipitation) Murai et al., Int J Cancer 2001*
• IRef Biogrid Interaction: CCND2 — CDK4 (physical association, affinity chromatography technology) Kehn et al., Retrovirology 2004*
• IRef Biogrid Interaction: CCND2 — CDK4 (physical association, affinity chromatography technology) Sweeney et al., Oncogene 1997*
• IRef Biogrid Interaction: CCND2 — CDK4 (physical association, affinity chromatography technology) Lin et al., Oncogene 2001*
• MIPS CORUM p16-cyclin D2-CDK4 complex: p16-cyclin D2-CDK4 complex complex (CCND2-CDK4-CDKN2A) Hirai et al., Mol Cell Biol 1995*
• MIPS CORUM CCND2-CDK4 complex: CCND2-CDK4 complex complex (CCND2-CDK4) Lundberg et al., Mol Cell Biol 1998*
• MIPS CORUM p34(SEI-1)-CDK4-CyclinD2 complex: p34(SEI-1)-CDK4-CyclinD2 complex complex (CCND2-CDK4-SERTAD1) Li et al., Biochemistry 2004*
• IRef Corum Interaction: CCND2 — CDK4 (association, coimmunoprecipitation) Lundberg et al., Mol Cell Biol 1998*
• IRef Corum Interaction: Complex of CDKN2A-CCND2-CDK4 (association, anti bait coimmunoprecipitation) Hirai et al., Mol Cell Biol 1995*
• IRef Dip Interaction: CCND2 — CDK4 (physical association, coimmunoprecipitation) Blain et al., J Biol Chem 1997*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Hirai et al., Mol Cell Biol 1995*
• IRef Hprd Interaction: Complex of 13 proteins (in vivo) Li et al., Biochemistry 2004*
• IRef Hprd Interaction: CCND2 — CDK4 (in vitro) Decker et al., Leukemia 2002*
• IRef Intact Interaction: CCND2 — CDK4 (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004
• IRef Intact Interaction: CCND2 — CDK4 (physical association, anti bait coimmunoprecipitation) Decker et al., Leukemia 2002*
• IRef Ophid Interaction: CCND2 — CDK4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome