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BMP6 — FGF8

Text-mined interactions from Literome

Anderson et al., Development 2002 (Craniofacial Abnormalities...) : Ectopic application of BMP2 to wild-type cephalic explants results in decreased FGF8 and SHH expression in rostral tissue, suggesting that the decreased expression of FGF8 and SHH observed in vivo is due to ectopic BMP activity
Xu et al., Cell stem cell 2008 : Using a defined medium, we show here that both TGFbeta and FGF signals synergize to inhibit BMP signaling ; sustain expression of pluripotency associated genes such as NANOG, OCT4, and SOX2 ; and promote long-term undifferentiated proliferation of human ESCs
Boswell et al., Dev Biol 2008 : Although BMP signaling is required for FGF to enhance fiber differentiation, the converse is not true
Lee et al., Biochim Biophys Acta 2009 : This process requires, at least in part, the inhibition of BMP signalling in the ectoderm by noggin, as well as FGF receptor activation and Ca2+ signalling
Huang et al., Development 2009 : FGF regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate
Mackem et al., Science signaling 2009 : In turn, SHH activity maintains the expression of Gremlin1, which encodes a bone morphogenetic protein ( BMP ) antagonist ; the interaction between BMP and Gremlin1 regulates Fgf gene expression
Miyoshi et al., Mol Cell Endocrinol 2010 : Since the SAPK/JNK inhibitor inhibited FGF-8 effects in upregulating Id-1 transcription, SAPK/JNK appears to be involved in the mechanism by which FGF-8 enhances BMP-Smad signaling
Tirosh-Finkel et al., Development 2010 : BMP mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
Yardley et al., Dev Biol 2012 : Finally, we report that prior to the upregulation of these neural crest markers, the non-neural ectoderm upregulates both BMP and Wnt molecules in response to FGF
Lupo et al., Open biology 2013 : We show that either BMP inhibition or activation of FGF signalling is required for effective neural induction, but these two pathways have distinct outcomes on rostrocaudal patterning